Virtual tissue constructs to assess the potential of electrical impedance spectroscopy as a method for tissue identification and pathology diagnosis

Malwina Matella^1,2, Keith Hunter³, Zi-Qiang Lang^1,2, Zhicheng Lin^1,2, Dawn Walker^1,2

¹Department of Computer Science, University of Sheffield, United Kingdom; ²Insigneo Institute of in silico Medicine, University of Sheffield, United Kingdom; ³Liverpool Head and Neck Centre, Molecular and Clinical Cancer Medicine, University of Liverpool

Can riot-control water cannon be lethal?

Yinze LEI¹, Jing XIE¹, María González García², Daniel Rittel³

¹Beijing Institute of Technology, 100081, Beijing, China; ²Department of Biomechanics and Accident Research, Ludwig-Maximilians-University Munich, Munich, Germany.; ³Faculty of Mechanical Engineering, Technion - Israel Institute of Technology, 32000 Haifa, Israel

In silico modelling of the effect of vaping on pulmonary surfactant dynamics from alveolus to whole lung

Ruobing Li, Alys Clark, Merryn Tawhai, David Nickerson, Kelly Burrowes

Auckland Bioengineering Institute, University of Auckland, New Zealand

How does utero-placental vascular structure drive Doppler ultrasound?

Nipuni D. Nagahawatte¹, Toby Jackson¹, Joanna James², Alys R. Clark¹

¹Auckland Bioengineering Institute, University of Auckland, New Zealand; ²Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand

Exploring the interaction between electrical stimulation and cells by an image-based digital twin

Vien Lam Che¹, Meike Bielfeldt², Nils Arbeiter¹, Barbara Nebe², Ursula van Rienen¹, Julius Zimmermann^1,3

¹University of Rostock, Germany; ²Rostock University Medical Center; ³University of Pavia

Using sequential nephron segment simulation to understand mechanisms of diuretic resistance

W Andrew Pruett¹, Marion Wofford², John S Clemmer¹, Robert L Hester¹

¹Department of Physiology, University of Mississippi Medical Center, United States of America; ²Department of Medicine, University of Mississippi Medical Center, United States of America

Agent-based simulation of diffusion-MRI for the characterization of NASH

Charles Boulitrop, Jiři Pešek, Dirk Drasdo

Group SIMBIOTX, INRIA Saclay, 91120 Palaiseau, France

Role of conduction channels in ventricular arrhythmias: Insights from in silico simulation and clinical data

Javier Villar-Valero¹, Juan F Gomez², David Soto-Iglesias³, Diego Penela³, Antonio Berruezo³, Beatriz Trenor¹

¹Centro de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, Valencia, Spain; ²Valencian International University, Valencia, Spain; ³Arrhythmia Department, Heart Institute, Teknon Medical Center, Barcelona, Spain

Electrical power and energy distributions in AF activation could direct to areas of rotor stabilization

Guadalupe Garcia-Isla¹, Yaiza Sánchez¹, Laura Martínes-Mateu², Javier Saiz¹, Omer Berenfeld³

¹Universitat Politècnica de València, Valencia, Spain; ²Universidad Rey Juan Carlos, Madrid, Spain; ³University of Michigan, Ann Abor, Michigan, USA

Inform design of a pulmonary artery pressure sensor using virtual cohorts

Jan Brüning^1,2, Adriano Schlief^1,2, Pavlo Yevtushenko^1,2, Jan Romberg³, Andreas Arndt^3,4,5, Leonid Goubergrits^1,2

¹Institute of Computer-assisted Cardiovascular Medicine, Charité – Universitätsmedizin Berlin; ²Deutsches Herzzentrum der Charité; ³Biotronik SE & Co. KG; ⁴Technische Universität Dresden, Germany; ⁵Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., Meinsberg, Germany

Modelling sodium transport in kidney tubuloids

Sangita Swapnasrita^1,2, Anita Layton³, Aurelie MF Carlier¹

¹Maastricht University, the Netherlands; ²UMC Utrecht, the Netherlands; ³University of Waterloo, Canada

Utilising self-similarity to model the morphometry of the pulmonary arteries

Atefeh Rahimi¹, Joyce John¹, Alys Clark¹, Kelly Burrowes¹, Farbod N Rahaghi², Raul San Jose Estepar², Merryn Tawhai¹

¹University Of Auckland, Bioengineering Institute, New Zealand; ²Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS)

3D model of the iliac vein unification – Sensitivity analysis

Magdalena Otta^1,2,3, Jan Meizner¹, Ian Halliday^2,3, Maciej Malawski^1,5, Chung Lim⁴, Janice Tsui^4,6, Andrew Narracott^2,3

¹Sano Centre for Computational Medicine, Poland; ²Division of Clinical Medicine, University of Sheffield, United Kingdom; ³Insigneo Institute for in silico medicine, University of Sheffield, United Kingdom; ⁴Royal Free London NHS Foundation Trust, United Kingdom; ⁵Institute of Computer Science, AGH University of Science and Technology, Kraków, Poland; ⁶University College London, London, UK

Evaluating the flow convergence method in mitral regurgitation analysis: Insights from computational fluid dynamics and pulsatile in-vitro studies

Alexander Stroh¹, Robin Leister¹, Roger Karl^2,3, Lubov Stroh⁴, Derliz Mereles³, Matthias Eden³, Luis Neff⁴, Raffaele de Simone², Gabriele Romano², Matthias Karck², Christoph Lichtenstern⁴, Norbert Frey³, Jochen Kriegseis¹, Bettina Frohnapfel¹, Sandy Engelhardt^2,3

¹Institute of Fluid Mechanics (ISTM), Karlsruhe Institute of Technology (KIT), Germany; ²Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany.; ³Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany; ⁴Department of Anaesthesiology, Heidelberg University Hospital, Heidelberg, Germany

In-silico design of wearable- and model-driven digital twins for cardiovascular disease monitoring

Bianca Maria Laudenzi, Lucas Omar Müller

University of Trento, Italy

Parameter estimation from undersampled MRI in frequency space

Miriam Löcke, Cristobal Bertoglio

University of Groningen, Netherlands, The

Computational study of the assessment of atria vulnerability to mutation-induced AF in 3D human atria

Rebecca Belletti¹, Joaquín Osca², Lucia Romero Perez¹, Javier Saiz¹

¹Universitat Politecnica de Valencia, Spain; ²Hospital Universitari i Politecnic La Fe, Valencia, Spain

Mapping persistent atrial fibrillation dynamics: Insights from electro-optic flow analysis in a virtual patient population

Ovais Ahmed Jaffery, Alexander Zolotarev, Carlos E. Barrera, Cristobal Rodero, Steven Niederer, Edward J. Vigmond, Wilson W.Good, Gregory Slabaugh, Caroline H. Roney

Queen Mary University of London, United Kingdom

Integrating care: Abalietas as a bridge between clinical quality registers and electronic medical records for enhanced machine learning applications in healthcare

Krzysztof Gądek, Rafał Niżankowski, Adam Nowak, Dominik Radziszowski, Joanna Twaróg, Maja Więckiewicz

Sano – Centre for Computational Personalised Medicine International Research Foundation, Poland

PyPopSim: Form single simulation to population studies

Jeremy Laforet, Sofiane Boudaoud

Université de Technologie de Compiègne, Alliance Sorbonne Universités, CNRS, UMR 7338 Biomécanique et Bio-ingénierie, Centre de recherche Royallieu, CS 60 319 Compiègne, France

Towards international standardization of computational modeling and simulation in the field of medical devices

Charlott Danielson

Fraunhofer IMTE, Germany

A physiologically based digital twin for alcohol consumption – Predicting real-life drinking responses and long-term plasma PEth

Henrik Podéus¹, Christian Simonsson¹, Patrik Nasr¹, Mattias Ekstedt¹, Stergios Kechagias¹, Peter Lundberg¹, William Lövfors^1,2, Gunnar Cedersund^1,2

¹Linköping University, Sweden; ²Örebro University, Sweden

Hipathia and metabolizer: Unveiling disease mechanisms and enabling personalized medicine

Kinza Rian, Joaquin Dopazo

Andalusian Platform for Computational Medicine, Spain

In silico modeling of cell migration over texturally treated curved surfaces

Majid Nazemi¹, Liesbet Geris^1,2,3,4

¹Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Belgium; ²Prometheus, division of Skeletal Tissue Engineering , KU Leuven, Belgium; ³Biomechanics Section, KU Leuven, Belgium; ⁴Skeletal Biology & Engineering Research Center, KU Leuven, Belgium

Systematic understanding and categorization of modeling & simulation context of use in knee biomechanics

Snehal Chokhandre, Ahmet Erdemir

Cleveland Clinic, United States of America

Sensitivity analysis of a finite element model predicting the fixation stability of tibial plateau fractures

Simon Comtesse^1,2, Alexander Crotta¹, Arvind von Keudell^2,3,4, Stephen J. Ferguson¹, Thomas Zumbrunn²

¹Institute for Biomechanics, ETH Zürich, Switzerland; ²CustomSurg AG, Switzerland; ³Brigham and Women's Hospital, Harvard Medical School, Boston, USA; ⁴Bispebjerg Hospital, Copenhagen, Denmark

Designing a single-use novel surgical kit for a cervical facet cage implantation through iterative FE simulations

Luca Ciriello¹, Tomaso Villa^1,2

¹Department of Chemistry, Materials and Chemical Engineering “Giulio Natta” - LaBS, Politecnico di Milano (Italy); ²IRCCS Istituto Ortopedico Galeazzi (Italy)

3D optical scanning toward personalised whole-body models

Alexander Dixon¹, Robin Laven¹, Poul Nielsen^1,2

¹Auckland Bioengineering Institute, University of Auckland, New Zealand; ²Department of Engineering Science, University of Auckland, New Zealand

A machine learning-based in silico assessment to predict human respiratory irritants and toxicity

Yunendah Nur Fuadah, Lulu Firdaus, Ki Moo Lim

Kumoh National Institue of Technology, Korea, Republic of (South Korea)

Unsupervised learning for MRI cross-scanner harmonization

Grace Wen¹, Alan Wang^1,3,4,, Vickie Shim^1,2,4, Samantha Holdsworth^2,3,4

¹Auckland Bioengineering Institute, University of Auckland, New Zealand; ²Mātai Medical Research Institute, Gisborne, New Zealand; ³Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; ⁴Centre for Brain Research, University of Auckland, New Zealand