In-silico analysis of physiological joint mechanics within a complex musculoskeletal leg-system and its application to biomechanical evaluation of implants

Okan Avci¹, Animesh Ranjan², Armagan Can Yildiz³

¹Fraunhofer IPA, Germany; ²Fraunhofer IPA, Germany; ³Fraunhofer IPA, Germany

Development of a validated software framework for in-silico clinical trials of orthopedic devices

Lukas Connolly, Christine Mueri, Adam Henderson

Zimmer Biomet, Switzerland

In silico clinical trial to predict the efficacy of alendronate for preventing hip fractures

Sara Oliviero^1,2, Giacomo Savelli^1,2, Antonino Amedeo La Mattina², Sophie Nguyen^1,3, Marco Viceconti^1,2

¹Department of Industrial Engineering, Alma Mater Studiorum, University of Bologna, Italy; ²Medical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; ³Department of Mechanical Engineering, Biomechanics Section, KU Leuven, Belgium

Assessing hip implant stability: A parametric surrogate modelling approach

Marlis Reiber^1,2, Fynn Bensel^1,3, Udo Nackenhorst^1,2,3

¹Leibniz University Hannover, Institute of Mechanics and Computational Mechanics, Appelstraße 9a, Hannover, 30167, Germany; ²Hannover Medical School, TRR ²⁹⁸Safety Integrated and Infection Reactive Implants (SIIRI), Carl-Neuberg-Straße 1, Hannover, 30625, Germany; ³Leibniz University Hannover, International Research Training Group (IRTG) 2657, Appelstraße 11/11a, Hannover, 30167, Germany

In silico clinical trial for a regulatory submission of a total shoulder arthroplasty system

Christine Mueri¹, Ghislain Maquer¹, Henderson Adam¹, Connolly Lukas¹, Maged Awadalla², Jeff Bischoff², Philippe Favre¹

¹Zimmer Biomet, Switzerland; ²Zimmer Biomet, USA