Conference Agenda

9:00am - 9:15am
6.H: 1

Prediction of higher airway particle deposition in children compared with adults: A modelling study

Ge Jin, Megan Soo, Kelly Burrowes, Ho-Fung Chan, Merryn Tawhai

Auckland Bioengineering Institute, New Zealand

9:15am - 9:30am
6.H: 2

Towards a virtual embryo: Computational modeling of neural tube closure defects

Job H. Berkhout^1,2, James A. Glazier³, Aldert Piersma^1,2, Julio M. Belmonte⁴, Juliette Legler², Richard M. Spencer⁵, Thomas B. Knudsen⁵, Harm J. Heusinkveld¹

¹Utrecht University, The Netherlands; ²IRAS, Utrecht University, The Netherlands; ³Biocomplexity Institute, Indiana University, Bloomington, United States; ⁴Department of Physics, NC State University, Raleigh, North Carolina, United States; ⁵U.S. EPA/ORD, Research Triangle Park, North Carolina, United States

9:30am - 9:45am
6.H: 3

Development of a multiscale data-driven lung model to understand the health effects of vaping

Marzieh Aghababaie¹, Peter Hunter¹, Sue McGlashan², Vinod Suresh¹, Merryn Tawhai¹, Kelly Burrowes¹

¹Auckland Bioengineering Institute, University of Auckland, New Zealand; ²Department of Anatomy & Medical Imaging, University of Auckland, New Zealand

9:45am - 10:00am
6.H: 4

Building disease ontology maps: In silico tools for applications in toxicology

Bernard Staumont¹, Luiz Ladeira¹, Alessio Gamba¹, Anouk Verhoeven², Julen Sanz Serrano², Eliška Kuchovská³, Job Berkhout⁴, Devon A. Barnes⁵, Marc Teunis⁶, Thomas H. Luechtefeld⁷, Thomas Hartung⁸, Ramiro Jover⁹, Tamara Vanhaecke², Ellen Fritsche^3,10, Harm J. Heusinkveld⁴, Aldert Piersma^4,11, Rosalinde Masereeuw⁵, Mathieu Vinken², Liesbet Geris^1,12

¹Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Liège, Belgium; ²Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Brussels, Belgium; ³IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; ⁴Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; ⁵Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands; ⁶Innovative Testing in Life Sciences & Chemistry, University of Applied Sciences Utrecht, The Netherlands; ⁷ToxTrack, Baltimore, MD, USA; ⁸Center for Alternatives to Animal Testing (CAAT) - Europe, University of Konstanz, Germany; CAAT, Johns Hopkins University, Baltimore, MD, USA; Johns Hopkins University, Doerenkamp-Zbinden Chair for Evidence-based Toxicology, Baltimore, MD, USA; ⁹Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, Valencia, Spain; Experimental Hepatology and Liver Transplant Unit, Health Research Institute La Fe, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; ¹⁰Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; ¹¹Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; ¹²Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium

10:00am - 10:15am
6.H: 5

Modelling toxicity after prostate cancer radiotherapy using genetically guided pixel-wise analysis

Tiziana Rancati¹, Eliana Gioscio¹, Michela Carlotta Massi², Nicola Rares Franco², Petra Seibold³, Barbara Avuzzi¹, Alessandro Cicchetti¹, Barry Rosenstein⁴, David Azria⁵, Ananya Choudhury⁶, Dirk De Ruysscher⁷, Maarten Lambrecht⁸, Elena Sperk⁹, Christopher J. Talbot¹⁰, Ana Vega¹¹, Liv Veldeman¹², Adam Webb¹¹, Paolo Zunino², Anna Maria Paganoni², Francesca Ieva², Andrea Manzoni², Sarah L. Kerns¹³, Alison Dunning¹⁴, Sara Gutierrez-Enriquez¹⁵, Jenny Chang-Claude³, Catharine M. L. West⁶

¹Fondazione IRCCS - Istituto Nazionale dei Tumori, Italy; ²Politecnico di Milano, Italy; ³German Cancer Research Center (DKFZ), Germany; ⁴Icahn School of Medicine at Mount Sinai, US; ⁵Université de Montpellier, France; ⁶University of Manchester, UK; ⁷Maastricht University Medical Centre, The Netherland; ⁸University Hospitals Leuven, Belgium; ⁹University Medical Centre Mannheim, Germany; ¹⁰University of Leicester, UK; ¹¹Fundaciòn Pùblica Galega Medicina Xenòmica, Spain; ¹²Ghent University Hospital, Belgium; ¹³Medical College of Wisconsin, US; ¹⁴University of Cambridge, UK; ¹⁵Vall d'Hebron Institute of Oncology, Spain

10:15am - 10:30am
6.H: 6

Virtual Cornea: A computational approach for predicting corneal injury and recovery from chemical exposures

Joel Vanin¹, Michael Getz¹, James A. Glazier¹, Thomas B. Knudsen², Catherine Mahony³

¹Department of Intelligent Systems Engineering and Biocomplexity Institute, Indiana University, Bloomington, IN;; ²Center for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC;; ³Procter & Gamble, Technical Centre, Reading, United Kingdom