Computational models of cardiac function – Closing the gaps between virtual and physical reality

Gernot Plank

Medical University of Graz, Austria

A multiscale finite element model of cardiac growth and baroreflex regulation

Hossein Sharifi¹, Kenneth Scott Campbell¹, Lik Chuan Lee², Jonathan Frederick Wenk¹

1: University of Kentucky, United States of America; 2: Michigan State University, United States of America

Full personalisation of 3D biventricular models from electroanatomical mappings and cardiac magnetic resonance imaging to understand the impact of arrhythmic substrate components on electrophysiological function

Jesus Jairo Rodríguez Padilla¹, Buntheng Ly², Rafael Silva¹, Mihaela Pop^1,3, Maxime Sermesant¹

1: Centre Inria d'Université Côte d'Azur, France; 2: IHU-Liryc, Université de Bordeaux, Pessac, France; 3: Sunnybrook Research Institute, Toronto, Canada

A multi-scale analysis of the impact of measurement and physiological uncertainty on electrocardiograms

Ludovica Cicci¹, Shuang Qian², Cristóbal Rodero¹, Fernando O. Campos², Marina Strocchi^1,2, Karli Gillette³, Gernot Plank^3,4, Martin J. Bishop², Steven A. Niederer^1,2,5

1: Imperial College London; 2: King's College London; 3: Medical University of Graz; 4: BioTechMed-Graz; 5: The Alan Turing Institute

Titin-mediated viscoelastic passive muscle mechanics

Filip Jezek¹, Anthony Baker³, David Nordsletten², Dan A Beard¹

1: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; 2: Departments of Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA; 3: Veterans Affairs Medical Center, San Francisco, CA, and Department of Medicine, University of California, San Francisco, CA, USA

CANCELLED - High-speed real heart simulations using a neural network finite element approach

Shuti Motiwale, Michael S Sacks

University of Texas at Austin, United States of America

Adaptive reduced-order models for cardiac simulations

Sridhar Chellappa¹, Barış Cansız², Lihong Feng¹, Peter Benner¹, Michael Kaliske²

1: Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany; 2: Institute for Structural Analysis, Technische Universität Dresden, 01062 Dresden, Germany

Surrogate modeling of finite deformation hyperelasticity of human myocardial tissue

Osman Gültekin, Baris Cansiz, Ahmad Moeineddin, Michael Kaliske

Technische Universität Dresden, Germany

Bridging computational efficiency, sex differences, and clinical accuracy: Surrogate modeling in cardiotoxicity assessment

Alberto Zingaro¹, Paula Dominguez¹, Caterina Balzotti¹, Laura Baldo¹, Jazmin Aguado Sierra¹, Mariano Vazquez^1,2

1: ELEM Biotech SL, Barcelona, Spain; 2: Barcelona Supercomputing Center, Barcelona, Spain

Physiology-informed machine learning to guide heart failure diagnosis, prognosis, and treatment

Feng Gu, Brian Carlson, Filip Jezek, Daniel Beard

University of Michigan, United States of America

An experimental and modelling pipeline to develop metabolite-sensitive cardiac cross-bridge models

Julia H Musgrave¹, June-Chiew Han¹, Marie-Louise Ward², Andrew J Taberner^1,3, Kenneth Tran¹

1: Auckland Bioengineering Institute, University of Auckland, New Zealand; 2: Department of Physiology, University of Auckland, New Zealand; 3: Department of Engineering Science and Biomedical Engineering, University of Auckland, New Zealand

Towards a realistic digital twins of coronary artery disease: Is a fluid-structure interaction simulations necessary?

Vittorio Lissoni, Marco Stefanati, Gabriele Dubini, Jose Felix Rodriguez Matas, Giulia Luraghi, Francesco Migliavacca

Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Italy

New perspectives on global sensitivity analysis for the creation of cardiovascular digital twins

Harry Saxton¹, Xu Xu², Torsten Schenkel³, Ian Halliday⁴

1: Materials & Engineering Research Institute, Sheffield Hallam University, Sheffield, United Kingdom; 2: Department of Computer Science, University of Sheffield, Sheffield; 3: Department of Engineering and Mathematics Sheffield Hallam University Sheffield, S1 1WB; 4: Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

Digital-twin based assessment of atrial arrhythmias: Influence of anatomical and functional personalization strategies

Patricia Martínez Díaz¹, Jorge Sánchez², Albert Dasí³, Christian Götz^1,4, Laura Anna Unger^1,5, Nikola André Fitzen¹, Annika Haas⁵, Ursula Ravens⁶, Armin Luik⁵, Olaf Dössel¹, Axel Loewe¹

1: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT); 2: Institute of Information and Communication Technologies (ITACA), Universitat Politècnica de València (UPV), Valencia, Spain; 3: Department of Computer Science, University of Oxford, Oxford, United Kingdom; 4: Department of Cardiology, University Hospital Heidelberg, Heidelberg Germany; 5: Städtisches Klinikum Karlsruhe, Karlsruhe, Germany; 6: Universitätsklinikum Freiburg, Freiburg, Germany

Advancements in multiphysics and multiscale modeling: Connecting computational cardiology with digital twinning

Luca Dede'

MOX-Mathematics Department, Politecnico di Milano, Italy

Next generation cardiac care: SimCardioTest cloud-based platform

Alessia Baretta¹, Yves Coudière², Oscar Camara³, Beatriz Trenor⁴, Hermenegild Arevalo⁵, Irene Balelli⁶, Romano Setzu⁷, Liesbet Geris⁸, Sylvain Benito⁹, Michele Barbier⁶, Maxime Sermesant⁶

1: InSilicoTrials Technologies, Italy; 2: Universite de Bordeaux, Bordeaux, France; 3: Universidad Pompeu Fabra, Barcelona, Spain; 4: Universitat Politecnica de Valencia, Valencia, Spain; 5: Simula Research Laboratory, Oslo, Norway; 6: Institut National De Recherche En informatique et Automatique, Sophia Antipolis, France; 7: Microport CRM, Clamart, France.; 8: VPH Institute, Leuven, Belgium; 9: Exact Cure, Nice, France

Uncertainty estimation in patient-specific cardiovascular models: The effect of sources of errors in 4D flow MRI and blood pressure

Kajsa Tunedal^1,2, Tino Ebbers^2,3, Gunnar Cedersund^1,2

1: Department of Biomedical Engineering, Linköping University, Linköping, Sweden; 2: Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; 3: Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden

Computational modeling of desmoplakin cardiomyopathy

Javiera Jilberto, Adam Helms, David Nordsletten

University of Michigan, United States of America

Determination of stimulation threshold in a 3D model of a pacemaker

Valentin Pannetier¹, Michael Leguèbe¹, Yves Coudière¹, Guilhem Faure², Delphine Feuerstein²

1: Université de Bordeaux / IHU Liryc / Inria, France; 2: Microport CRM, France

Development of an automated pipeline for large-scale in silico trials in patient-specific electromechanical ventricular models

Ruben Doste¹, Julia Camps¹, Zhinuo Jenny Wang¹, Lucas Arantes Berg¹, Marcel Beetz², Abhirup Banerjee², Vicente Grau², Blanca Rodriguez¹

1: Department of Computer Science, University of Oxford, United Kingdom; 2: Department of Engineering Science, University of Oxford, United Kingdom

A strongly coupled electromechanical model of heart failure as a benchtest for proarrhythmia assessment and drug testing

Eva Casoni¹, Jazmin Aguado-Sierra¹, Maite Mora³, Sergi Picó², Juan Francisco Gómez³, Mariano Vázquez^1,2, Beatriz Trenor³

1: ELEM Biotech, Spain; 2: Barcelona Supercomputing Center, Spain; 3: Universitat Politècnica de València, Spain

Personalisation of action potentials based on activation recovery intervals in post-infarcted pigs: A simulation study

Jesus Jairo Rodríguez Padilla¹, Rafael Silva¹, Buntheng Ly², Mihaela Pop¹, Maxime Sermesant¹

1: Centre Inria d'Université Côte d'Azur, France; 2: IHU Liryc, Université de Bordeaux, France

Instantaneous biomechanical model of the heart to characterize ventricular remodeling in complex congenital heart disease

Maria Gusseva¹, Nikhil Thatte², Daniel A. Castellanos², Peter E. Hammer³, Sunil J. Ghelani², Ryan Callahan⁴, Tarique Hussain¹, Radomir Chabiniok¹

1: UT Southwestern Medical Center, United States of America; 2: Department of Cardiology, Boston Children’s Hospital, Boston, MA, USA; 3: Department of Cardiac Surgery, Boston Children’s Hospital, Boston, MA, USA; 4: Division of Cardiology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

Construction and manufacturing of an MRI-ready experimental left heart phantom model

Moritz Wiegand¹, Tim Bierewirtz¹, Leonid Goubergrits^1,2, Katharina Vellguth¹

1: ICM, Deutsches Herzzentrum der Charité, Germany; 2: Einstein Center Digital Future

Predicting cardiac conduction disturbances during balloon aortic valvuloplasty from patient-specific computational models

Benjamin Ayo Matheson^1,2, Haoran Dou^1,2, Cristina Teleanu^1,2, George Hyde-Linaker³, Rebecca Bryan³, David Flynn⁴, Daniel Blackman⁵, Toni Lassila^1,2, Nishant Ravikumar^1,2, Alejandro F. Frangi^1,6,7, Zeike A. Taylor^1,2

1: Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB); 2: University of Leeds, United Kingdom; 3: Synopsys, Inc.; 4: Boston Scientific Corporation; 5: Leeds Teaching Hospitals NHS Foundation Trust; 6: Christabel Pankhurst Institute; 7: University of Manchester, United Kingdom

Hierarchical VVUQ strategy for the development and credibility assessment of a pulmonary heart valve model

Nils Götzen¹, Tahir Turgut¹, Omar Zahalka¹, Vincent Bouwman¹, Mikel Isasi², Malte Rolf-Pissarczyk³, Rick van Tunen⁴, Mathias Peirlinck⁴, Mohammad Mirzaali⁴

1: 4RealSim Services BV, Netherlands, The; 2: Leartiker, Spain; 3: TU-Graz, Austria; 4: TU-Delft, Netherlands, The

Predictive model for the assessment of the TEVAR procedure

Sara Barati¹, Giulia Luraghi¹, Anna Ramella¹, Benedetta Grossi², Francesco Migliavacca¹, Josè Felix Rodriguez Matas¹

1: Politecnico di Milano, Italy; 2: Humanitas University, IT

Alterations of the in vivo myocardium mechanical properties in aortic stenosis: Finite element analysis in a rat model

Mohammad Javad Sadeghinia¹, Henrik Nicolay Finsberg¹, Emil Espe^2,3, Ida Marie Hauge-Iversen^2,3, Lili Zhang^2,3, Einar S. Nordén^2,3, Ivar Sjaastad^2,3, Samuel Wall¹, Joakim Sundnes¹

1: Simula Research Laboratory, Oslo, Norway; 2: Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway; 3: K.G. Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway

Data-driven analysis of modelling approaches for distal vessel trees in coronary blood flow

Jack Lee, Mohammed Salim Ibrahim

King's College London, United Kingdom

An integrated computational model for coronary and myocardial blood flow applied in a clinical diagnostic setting

Giovanni Montino Pelagi¹, Andrea Baggiano², Francesco Regazzoni³, Jacques Huyghe⁴, Marco Alì⁵, Silvia Bertoluzza⁶, Gianluca Pontone², Giovanni Valbusa⁵, Christian Vergara¹

1: LABS, DCMC, Politecnico di Milano, Italy; 2: Cardiovascular Imaging Department, Centro Cardiologico Monzino, Italy; 3: MOX, DMAT, Politecnico di Milano, Italy; 4: School of Engineering, University of Limerick, Ireland; 5: Bracco Imaging S.p.A., Italy; 6: IMATI, CNR, Italy

Computational modeling of myocardial perfusion and oxygen transport in coronary venous retroperfusion treatments

Haifeng Wang¹, Lei Fan², Jenny Choy³, Ghassan Kassab³, Lik-Chuan Lee¹

1: Michigan State University, USA; 2: Marquette University and Medical College of Wisconsin, USA; 3: California Medical Innovations Institute, USA

Integrating time-varying resistance in a lumped parameter model of the coronary circulation

Enhui Yong^1,2, Vivek Muthurangu¹, Ryo Torii²

1: Institute of Cardiovascular Science, University College London, London, UK; 2: Department of Mechanical Engineering, University College London, London, UK

Biventricular modelling of human heart with right ventricular outflow tract

Debao Guan¹, Mark Danton², Xiaoyu Luo¹, Hao Gao¹

1: University of Glasgow, United Kingdom; 2: Golden Jubilee National Hospital, Glasgow, United Kingdom

Examining flow dynamics after left atrial appendage occlusion using CFD simulations: Influence of device implant depth

Jordi Mill¹, Carlos Albors¹, Pedro Cepas-Guillen², Manal Barrouhou¹, Íñigo Anduaga², Laura Sanchis², Ana Laffond³, Ignacio Cruz-Gonzalez³, Xavier Freixa², Oscar Camara¹

1: Universitat Pompeu Fabra, Spain; 2: Department of Cardiology, Hospital Clinic Barcelona, Spain; 3: Department of Cardiology, Hospital Universitario de Salamanca, Spain