Articular cartilage systems mechanobiology: A multiscale tissue model of the knee cartilage

Andreu Pascuet-Fontanet, Maria Segarra-Queralt, Jérôme Noailly

BCN MedTech, Universitat Pompeu Fabra, Spain

Pixel2Mechanics: Automated biomechanical simulations of high-resolution intervertebral discs from anisotropic MRIs

Estefano Muñoz-Moya¹, Sai Natarajan^1,2, Morteza Rasouligandomani¹, Carlos Ruiz Wills¹, Francis Chemorion^1,4, Ludovic Humbert^2,3, Miguel A. González Ballester¹, Gemma Piella¹, Jérôme Noailly¹

1: BCN MedTech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain; 2: Galgo Medical S.L., Barcelona, Spain; 3: 3D-Shaper Medical S.L., Barcelona, Spain; 4: IT, Department of Information Technology, InSilicoTrials Technologies, Trieste, Italy

Computational modeling of articular cartilage mechanics: Insights and validation

Franziska S. Egli, Seyed Morteza Seyedpour, Tim Ricken

University of Stuttgart, Germany

Application of an FSI-based model to optimize mechanically stimulated structured hydrogel scaffolds for cartilage cell differentiation

Pedram Azizi, Christoph Drobek, Ursula van Rienen, Hermann Seitz

Universität Rostock, Germany

Model investigation of the energy density resulting from the absorption and scattering of radiation in multi-layer skin tissue structures

Seyed Morteza Seyedpour^1,2, Lena Lambers^1,2, Hans-Michael Tautenhahn³, Franziska Tautenhahn⁴, Tim Ricken^1,2

1: Institute of Structural Mechanics and Dynamics in Aerospace Engineering, Faculty of Aerospace Engineering and Geodesy, University of Stuttgart, Pfaffenwaldring, 27 Stuttgart, 70569, Germany; 2: Biomechanic Lab, Institute of Structural Mechanics and Dynamics in Aerospace Engineering, Faculty of Aerospace Engineering and Geodesy, University of Stuttgart , Pfaffenwaldring 27, Stuttgart, 70569, Germany; 3: Department of Visceral, Transplantation, Thoracic and Vascular Surgery, Leipzig University Hospital, Liebigstraße 20, Leipzig, 04103, Germany; 4: Clinic and OPD for Oral and Maxillofacial Surgery / Plastic Surgery, Am Klinikum 1, Jena 07747, Germany

Generality and applicability in developing virtual epithelial tissues models

Lorenzo Veschini¹, Joel Vanin¹, Michael Getz¹, Alison Stephens², Catherine Mahony², James A Glazier¹

1: Indiana University, United Kingdom; 2: Procter & Gamble

Digital twins for oncology and patient-specific simulations: Importance of vascularization

Diego Sainz-DeMena, Silvia Hervas-Raluy, Ángela Pérez-Benito, Maria Jose Gomez-Benito, José Manuel García-Aznar, María Ángeles Pérez

Department of Mechanical Engineering, Aragon Institute for Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain

Digital twin of prostate cancer tumour growth: A multiphysics approach

Ángela Pérez-Benito, María José Gómez-Benito, José Manuel García-Aznar, María Ángeles Pérez

Universidad de Zaragoza, Spain

Multiphasic modelling and patient-specific simulation of tumours in soft tissue with OncoFEM

Marlon Suditsch¹, Tim Ricken¹, Arndt Wagner²

1: Institute of Structural Mechanics and Dynamics, in Aerospace Engineering, University of Stuttgart, Germany; 2: Institute of Applied Mechanics (CE), University of Stuttgart, Germany

Modeling hypoxia-induced radiation resistance and the impact of radiation sources

Luca Possenti¹, Piermario Vitullo², Alessandro Cicchetti¹, Paolo Zunino², Tiziana Rancati¹

1: Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy; 2: MOX, Department of Mathematics, Politecnico di Milano, Italy

Efficient radial-shell model for 3D tumor spheroid dynamics with radiotherapy

Florian Franke¹, Sona Michlikova^2,3, Sebastian Aland^1,4,5, Leoni Kunz-Schughart^2,6, Anja Voss-Böhme¹, Steffen Lange^1,2

1: Faculty of Informatics/Mathematics, HTW Dresden - University of Applied Sciences (HTWD), Germany; 2: OncoRay - National Center for Radiation Research in Oncology, Technische Universität Dresden; 3: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology—OncoRay, Germany; 4: Faculty of Mathematics and Computer Science, TU Freiberg, Germany; 5: Center for Systems Biology Dresden (CSBD), Germany; 6: National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany

Computational synthesis of microvascular networks: A precision medicine approach to predict radiotherapy outcome in head and neck cancer

Sophie Materne^1,2, Luca Possenti¹, Alessandro Cicchetti¹, Francesco Pisani¹, Alessandra Catalano¹, Piermario Vitullo², Tiziana Rancati¹, Paolo Zunino²

1: Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Italy; 2: Department of Mathematics, Politecnico di Milano, Milan, Italy

Development and validation of a computational simulator for treatment outcome prediction in high-grade serous ovarian cancer

Marilisa Cortesi^1,2, Dongli Liu², Elyse Powell², Ellen Barlow², Kristina Warton², Emanuele Giordano¹, Caroline E. Ford²

1: University of Bologna, Italy; 2: University of New South Wales

Patient-specific modelling of needle insertion in prostate cancer therapy

Myrianthi Hadjicharalambous¹, Vasileios Vavourakis^1,2

1: University of Cyprus, Cyprus; 2: University College London, UK

METASTRA: Computer-aided effective fracture risk stratification of patients with vertebral metastases for personalised treatment through robust computational models validated in clinical settings

Luca Cristofolini¹, Giovanni Barbanti-Bròdano², Vincenzo Carbone³, Enrico Dall'Ara⁴, Stephen Ferguson⁵, Rudolf Ferenc⁶, Jose Manuel Garcia Aznar⁷, Niccole Germscheid⁸, Jakob Haardt⁹, Aron Lazary¹⁰, Marco Palanca¹, Nikolina Lednicki¹¹, Peter Vajkoczy¹², Jorrit-Jan Verlaan¹³, Laszlo Vidacs¹⁴, Emmanuelle Voisin¹⁵

1: Alma Mater Studiorum - University of Bologna, Italy; 2: Rizzoli Orthopaedic Institute, Italy; 3: InSilicoTrials Technologies, Italy; 4: University of Sheffield, UK; 5: Federal Institute of Technology ETH Zurich, Switzerland; 6: FrontEndArt, Hungary; 7: University of Zaragoza, Spain; 8: AOSpine, Switzerland; 9: Eurice, Germany; 10: Buda Health Center, Hungary; 11: Rise, Croatia; 12: Charité Universitätsmedizin Berlin, Germany; 13: University Medical Center Utrecht, Netherlands; 14: University of Szeged, Hungary; 15: Voisin Consulting Life Science, France

Clinical decision support during maintenance therapy for childhood acute lymphoblastic leukemia

Anna Gebhard¹, Sebastian Sager¹, Jakob Zierk², Markus Metzler², Manfred Rauh²

1: MathOpt group, Otto von Guericke University Magdeburg; 2: Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen

From novel muscular mechanics principles to neurotechnology for human movement

Can A. Yucesoy

Bogazici University, Turkiye

Integrating intraoperative testing with musculoskeletal modeling: Muscle force-length relationship in patients with cerebral palsy

Cemre Su Kaya Keles¹, Filiz Ates¹, Can A. Yucesoy²

1: Institute of Structural Mechanics and Dynamics in Aerospace Engineering, University of Stuttgart, Stuttgart, Germany; 2: Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Türkiye

The development of LSTM-based ankle position and moment estimator for powered ankle prosthesis using nonnormalized sEMG and feature inputs

Ahmet Dogukan Keles¹, Can A. Yucesoy²

1: Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany; 2: Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Türkiye

Boosting the performance of lightweight deep learning models with attention in human activity recognition

Özlem Durmaz¹, Sümeyye Ağaç²

1: University of Twente; 2: Bogazici University

Joint angle generation for human walking using conditional neural movement primitives

Mehmet Selcuk Albayrak, Muhammet Hatipoglu, Evren Samur, Emre Ugur

Bogazici University, Turkiye

Smartphone application for quantitative assessment of gait and balance impairments in stroke patients

Otar Akanyeti¹, Federico Villagra Povina¹, Arshad Sher^1,2, Magali Sganga^1,3,4

1: Aberystwyth University, United Kingdom; 2: Nottingham Trent University, United Kingdom; 3: Universidad Maimónides, Argentina; 4: Universidad Nacional de La Matanza, Argentina

Estimating daily dynamic skeletal loading from ankle-worn activity monitors after menopause

Emma Fortune¹, Omid Jahanian¹, Melissa M. Morrow², Michelle M. Mielke³

1: Mayo Clinic, Minnesota, United States of America; 2: The University Medical Branch Texas, Texas, United States of America; 3: Wake Forest University School of Medicine, North Carolina, United States of America

Validating the Fitbit Charge 6 wearable activity monitor for use in physical activity interventions in lung cancer: Study protocol

Roberto Benzo^1,2,3, Rujul Singh³, Carolyn Presley^1,2, Zach Chaplow⁴, Brian Focht⁴, Chloe Hery³, Macy Tetrick³, Allison Cleveland³, Jane Yu⁵, Emma Fortune⁶

1: Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.; 2: Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio, USA.; 3: Division of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.; 4: Kinesiology, Department of Human Sciences, The Ohio State University, USA.; 5: College of Medicine, The Ohio State University Columbus Ohio USA.; 6: Division of Health Care Delivery Research, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA.

Accelerating clinical decision making: Tailoring generic MSK models with subject-specific information is a good approximation to the personalized models

Pratik Nag^1,2, Alessandra Aldieri^1,2,3, Xinshan Li^4,5, Giorgio Davico^1,2, Marco Viceconti^1,2

1: Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Bologna, Italy; 2: Laboratorio di Tecnologia Medica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; 3: PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; 4: Department of Mechanical Engineering, University of Sheffield, Sheffield, UK; 5: INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, UK

Gait analysis of patients with spinal cord injury: Influence of postoperative rehabilitation

Sanyam Phutela¹, Mahshida Hamid¹, Rounak Bhattacharyya¹, Manish Gupta², Bhavuk Garg², Rajesh Malhotra^2,3, Madhusudan Pal^4,5, Anoop Chawla¹, Sudipto Mukherjee¹, Kaushik Mukherjee¹

1: Indian Institute of Technology Delhi, India; 2: All Indian Institute of Medical Sciences, New Delhi, India; 3: Indraprastha Apollo Hospital, New Delhi, India; 4: Defense Institute of Physiology & Allied Science, Defence Research & Development Organisation, Delhi, India; 5: Center of Excellence, Footwear Design & Development Institute, Noida, India

Prediction of higher airway particle deposition in children compared with adults: A modelling study

Ge Jin, Megan Soo, Kelly Burrowes, Ho-Fung Chan, Merryn Tawhai

Auckland Bioengineering Institute, New Zealand

Towards a virtual embryo: Computational modeling of neural tube closure defects

Job H. Berkhout^1,2, James A. Glazier³, Aldert Piersma^1,2, Julio M. Belmonte⁴, Juliette Legler², Richard M. Spencer⁵, Thomas B. Knudsen⁵, Harm J. Heusinkveld¹

1: Utrecht University, The Netherlands; 2: IRAS, Utrecht University, The Netherlands; 3: Biocomplexity Institute, Indiana University, Bloomington, United States; 4: Department of Physics, NC State University, Raleigh, North Carolina, United States; 5: U.S. EPA/ORD, Research Triangle Park, North Carolina, United States

Development of a multiscale data-driven lung model to understand the health effects of vaping

Marzieh Aghababaie¹, Peter Hunter¹, Sue McGlashan², Vinod Suresh¹, Merryn Tawhai¹, Kelly Burrowes¹

1: Auckland Bioengineering Institute, University of Auckland, New Zealand; 2: Department of Anatomy & Medical Imaging, University of Auckland, New Zealand

Building disease ontology maps: In silico tools for applications in toxicology

Bernard Staumont¹, Luiz Ladeira¹, Alessio Gamba¹, Anouk Verhoeven², Julen Sanz Serrano², Eliška Kuchovská³, Job Berkhout⁴, Devon A. Barnes⁵, Marc Teunis⁶, Thomas H. Luechtefeld⁷, Thomas Hartung⁸, Ramiro Jover⁹, Tamara Vanhaecke², Ellen Fritsche^3,10, Harm J. Heusinkveld⁴, Aldert Piersma^4,11, Rosalinde Masereeuw⁵, Mathieu Vinken², Liesbet Geris^1,12

1: Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Liège, Belgium; 2: Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Brussels, Belgium; 3: IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; 4: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; 5: Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands; 6: Innovative Testing in Life Sciences & Chemistry, University of Applied Sciences Utrecht, The Netherlands; 7: ToxTrack, Baltimore, MD, USA; 8: Center for Alternatives to Animal Testing (CAAT) - Europe, University of Konstanz, Germany; CAAT, Johns Hopkins University, Baltimore, MD, USA; Johns Hopkins University, Doerenkamp-Zbinden Chair for Evidence-based Toxicology, Baltimore, MD, USA; 9: Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, Valencia, Spain; Experimental Hepatology and Liver Transplant Unit, Health Research Institute La Fe, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; 10: Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; 11: Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; 12: Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium

Modelling toxicity after prostate cancer radiotherapy using genetically guided pixel-wise analysis

Tiziana Rancati¹, Eliana Gioscio¹, Michela Carlotta Massi², Nicola Rares Franco², Petra Seibold³, Barbara Avuzzi¹, Alessandro Cicchetti¹, Barry Rosenstein⁴, David Azria⁵, Ananya Choudhury⁶, Dirk De Ruysscher⁷, Maarten Lambrecht⁸, Elena Sperk⁹, Christopher J. Talbot¹⁰, Ana Vega¹¹, Liv Veldeman¹², Adam Webb¹¹, Paolo Zunino², Anna Maria Paganoni², Francesca Ieva², Andrea Manzoni², Sarah L. Kerns¹³, Alison Dunning¹⁴, Sara Gutierrez-Enriquez¹⁵, Jenny Chang-Claude³, Catharine M. L. West⁶

1: Fondazione IRCCS - Istituto Nazionale dei Tumori, Italy; 2: Politecnico di Milano, Italy; 3: German Cancer Research Center (DKFZ), Germany; 4: Icahn School of Medicine at Mount Sinai, US; 5: Université de Montpellier, France; 6: University of Manchester, UK; 7: Maastricht University Medical Centre, The Netherland; 8: University Hospitals Leuven, Belgium; 9: University Medical Centre Mannheim, Germany; 10: University of Leicester, UK; 11: Fundaciòn Pùblica Galega Medicina Xenòmica, Spain; 12: Ghent University Hospital, Belgium; 13: Medical College of Wisconsin, US; 14: University of Cambridge, UK; 15: Vall d'Hebron Institute of Oncology, Spain

Virtual Cornea: A computational approach for predicting corneal injury and recovery from chemical exposures

Joel Vanin¹, Michael Getz¹, James A. Glazier¹, Thomas B. Knudsen², Catherine Mahony³

1: Department of Intelligent Systems Engineering and Biocomplexity Institute, Indiana University, Bloomington, IN;; 2: Center for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC;; 3: Procter & Gamble, Technical Centre, Reading, United Kingdom