Virtual tissue constructs to assess the potential of electrical impedance spectroscopy as a method for tissue identification and pathology diagnosis

Malwina Matella^1,2, Keith Hunter³, Zi-Qiang Lang^1,2, Zhicheng Lin^1,2, Dawn Walker^1,2

1: Department of Computer Science, University of Sheffield, United Kingdom; 2: Insigneo Institute of in silico Medicine, University of Sheffield, United Kingdom; 3: Liverpool Head and Neck Centre, Molecular and Clinical Cancer Medicine, University of Liverpool

Can riot-control water cannon be lethal?

Yinze LEI¹, Jing XIE¹, María González García², Daniel Rittel³

1: Beijing Institute of Technology, 100081, Beijing, China; 2: Department of Biomechanics and Accident Research, Ludwig-Maximilians-University Munich, Munich, Germany.; 3: Faculty of Mechanical Engineering, Technion - Israel Institute of Technology, 32000 Haifa, Israel

In silico modelling of the effect of vaping on pulmonary surfactant dynamics from alveolus to whole lung

Ruobing Li, Alys Clark, Merryn Tawhai, David Nickerson, Kelly Burrowes

Auckland Bioengineering Institute, University of Auckland, New Zealand

How does utero-placental vascular structure drive Doppler ultrasound?

Nipuni D. Nagahawatte¹, Toby Jackson¹, Joanna James², Alys R. Clark¹

1: Auckland Bioengineering Institute, University of Auckland, New Zealand; 2: Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand

Exploring the interaction between electrical stimulation and cells by an image-based digital twin

Vien Lam Che¹, Meike Bielfeldt², Nils Arbeiter¹, Barbara Nebe², Ursula van Rienen¹, Julius Zimmermann^1,3

1: University of Rostock, Germany; 2: Rostock University Medical Center; 3: University of Pavia

Using sequential nephron segment simulation to understand mechanisms of diuretic resistance

W Andrew Pruett¹, Marion Wofford², John S Clemmer¹, Robert L Hester¹

1: Department of Physiology, University of Mississippi Medical Center, United States of America; 2: Department of Medicine, University of Mississippi Medical Center, United States of America

Agent-based simulation of diffusion-MRI for the characterization of NASH

Charles Boulitrop, Jiři Pešek, Dirk Drasdo

Group SIMBIOTX, INRIA Saclay, 91120 Palaiseau, France

Role of conduction channels in ventricular arrhythmias: Insights from in silico simulation and clinical data

Javier Villar-Valero¹, Juan F Gomez², David Soto-Iglesias³, Diego Penela³, Antonio Berruezo³, Beatriz Trenor¹

1: Centro de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, Valencia, Spain; 2: Valencian International University, Valencia, Spain; 3: Arrhythmia Department, Heart Institute, Teknon Medical Center, Barcelona, Spain

Electrical power and energy distributions in AF activation could direct to areas of rotor stabilization

Guadalupe Garcia-Isla¹, Yaiza Sánchez¹, Laura Martínes-Mateu², Javier Saiz¹, Omer Berenfeld³

1: Universitat Politècnica de València, Valencia, Spain; 2: Universidad Rey Juan Carlos, Madrid, Spain; 3: University of Michigan, Ann Abor, Michigan, USA

Inform design of a pulmonary artery pressure sensor using virtual cohorts

Jan Brüning^1,2, Adriano Schlief^1,2, Pavlo Yevtushenko^1,2, Jan Romberg³, Andreas Arndt^3,4,5, Leonid Goubergrits^1,2

1: Institute of Computer-assisted Cardiovascular Medicine, Charité – Universitätsmedizin Berlin; 2: Deutsches Herzzentrum der Charité; 3: Biotronik SE & Co. KG; 4: Technische Universität Dresden, Germany; 5: Kurt-Schwabe-Institut für Mess- und Sensortechnik Meinsberg e.V., Meinsberg, Germany

Modelling sodium transport in kidney tubuloids

Sangita Swapnasrita^1,2, Anita Layton³, Aurelie MF Carlier¹

1: Maastricht University, the Netherlands; 2: UMC Utrecht, the Netherlands; 3: University of Waterloo, Canada

Utilising self-similarity to model the morphometry of the pulmonary arteries

Atefeh Rahimi¹, Joyce John¹, Alys Clark¹, Kelly Burrowes¹, Farbod N Rahaghi², Raul San Jose Estepar², Merryn Tawhai¹

1: University Of Auckland, Bioengineering Institute, New Zealand; 2: Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS)

3D model of the iliac vein unification – Sensitivity analysis

Magdalena Otta^1,2,3, Jan Meizner¹, Ian Halliday^2,3, Maciej Malawski^1,5, Chung Lim⁴, Janice Tsui^4,6, Andrew Narracott^2,3

1: Sano Centre for Computational Medicine, Poland; 2: Division of Clinical Medicine, University of Sheffield, United Kingdom; 3: Insigneo Institute for in silico medicine, University of Sheffield, United Kingdom; 4: Royal Free London NHS Foundation Trust, United Kingdom; 5: Institute of Computer Science, AGH University of Science and Technology, Kraków, Poland; 6: University College London, London, UK

Evaluating the flow convergence method in mitral regurgitation analysis: Insights from computational fluid dynamics and pulsatile in-vitro studies

Alexander Stroh¹, Robin Leister¹, Roger Karl^2,3, Lubov Stroh⁴, Derliz Mereles³, Matthias Eden³, Luis Neff⁴, Raffaele de Simone², Gabriele Romano², Matthias Karck², Christoph Lichtenstern⁴, Norbert Frey³, Jochen Kriegseis¹, Bettina Frohnapfel¹, Sandy Engelhardt^2,3

1: Institute of Fluid Mechanics (ISTM), Karlsruhe Institute of Technology (KIT), Germany; 2: Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany.; 3: Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany; 4: Department of Anaesthesiology, Heidelberg University Hospital, Heidelberg, Germany

In-silico design of wearable- and model-driven digital twins for cardiovascular disease monitoring

Bianca Maria Laudenzi, Lucas Omar Müller

University of Trento, Italy

Parameter estimation from undersampled MRI in frequency space

Miriam Löcke, Cristobal Bertoglio

University of Groningen, Netherlands, The

Computational study of the assessment of atria vulnerability to mutation-induced AF in 3D human atria

Rebecca Belletti¹, Joaquín Osca², Lucia Romero Perez¹, Javier Saiz¹

1: Universitat Politecnica de Valencia, Spain; 2: Hospital Universitari i Politecnic La Fe, Valencia, Spain

Mapping persistent atrial fibrillation dynamics: Insights from electro-optic flow analysis in a virtual patient population

Ovais Ahmed Jaffery, Alexander Zolotarev, Carlos E. Barrera, Cristobal Rodero, Steven Niederer, Edward J. Vigmond, Wilson W.Good, Gregory Slabaugh, Caroline H. Roney

Queen Mary University of London, United Kingdom

Integrating care: Abalietas as a bridge between clinical quality registers and electronic medical records for enhanced machine learning applications in healthcare

Krzysztof Gądek, Rafał Niżankowski, Adam Nowak, Dominik Radziszowski, Joanna Twaróg, Maja Więckiewicz

Sano – Centre for Computational Personalised Medicine International Research Foundation, Poland

PyPopSim: Form single simulation to population studies

Jeremy Laforet, Sofiane Boudaoud

Université de Technologie de Compiègne, Alliance Sorbonne Universités, CNRS, UMR 7338 Biomécanique et Bio-ingénierie, Centre de recherche Royallieu, CS 60 319 Compiègne, France

Towards international standardization of computational modeling and simulation in the field of medical devices

Charlott Danielson

Fraunhofer IMTE, Germany

A physiologically based digital twin for alcohol consumption – Predicting real-life drinking responses and long-term plasma PEth

Henrik Podéus¹, Christian Simonsson¹, Patrik Nasr¹, Mattias Ekstedt¹, Stergios Kechagias¹, Peter Lundberg¹, William Lövfors^1,2, Gunnar Cedersund^1,2

1: Linköping University, Sweden; 2: Örebro University, Sweden

Hipathia and metabolizer: Unveiling disease mechanisms and enabling personalized medicine

Kinza Rian, Joaquin Dopazo

Andalusian Platform for Computational Medicine, Spain

In silico modeling of cell migration over texturally treated curved surfaces

Majid Nazemi¹, Liesbet Geris^1,2,3,4

1: Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Belgium; 2: Prometheus, division of Skeletal Tissue Engineering , KU Leuven, Belgium; 3: Biomechanics Section, KU Leuven, Belgium; 4: Skeletal Biology & Engineering Research Center, KU Leuven, Belgium

Systematic understanding and categorization of modeling & simulation context of use in knee biomechanics

Snehal Chokhandre, Ahmet Erdemir

Cleveland Clinic, United States of America

Sensitivity analysis of a finite element model predicting the fixation stability of tibial plateau fractures

Simon Comtesse^1,2, Alexander Crotta¹, Arvind von Keudell^2,3,4, Stephen J. Ferguson¹, Thomas Zumbrunn²

1: Institute for Biomechanics, ETH Zürich, Switzerland; 2: CustomSurg AG, Switzerland; 3: Brigham and Women's Hospital, Harvard Medical School, Boston, USA; 4: Bispebjerg Hospital, Copenhagen, Denmark

Designing a single-use novel surgical kit for a cervical facet cage implantation through iterative FE simulations

Luca Ciriello¹, Tomaso Villa^1,2

1: Department of Chemistry, Materials and Chemical Engineering “Giulio Natta” - LaBS, Politecnico di Milano (Italy); 2: IRCCS Istituto Ortopedico Galeazzi (Italy)

3D optical scanning toward personalised whole-body models

Alexander Dixon¹, Robin Laven¹, Poul Nielsen^1,2

1: Auckland Bioengineering Institute, University of Auckland, New Zealand; 2: Department of Engineering Science, University of Auckland, New Zealand

A machine learning-based in silico assessment to predict human respiratory irritants and toxicity

Yunendah Nur Fuadah, Lulu Firdaus, Ki Moo Lim

Kumoh National Institue of Technology, Korea, Republic of (South Korea)

Unsupervised learning for MRI cross-scanner harmonization

Grace Wen¹, Alan Wang^1,3,4,, Vickie Shim^1,2,4, Samantha Holdsworth^2,3,4

1: Auckland Bioengineering Institute, University of Auckland, New Zealand; 2: Mātai Medical Research Institute, Gisborne, New Zealand; 3: Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; 4: Centre for Brain Research, University of Auckland, New Zealand

Incorporating wearable sensor data into research workflows

Gregory B Sands, Hayden Randles, Poul M F Nielsen

Auckland Bioengineering Institute, University of Auckland, New Zealand

Modelling the neural regulation of gastric motility at the tissue level

Omkar N. Athavale, Recep Avci, Alys R. Clark, Leo K. Cheng, Peng Du

University of Auckland, New Zealand

Efficient numerical simulation of effective micro-macro models for reactive transport in elastic perforated media

Jonas Knoch¹, Nicolas Neuß¹, Markus Gahn², Maria Neuss-Radu^1,2

1: FAU Erlangen-Nürnberg, Germany; 2: Universität Heidelberg, Germany

The development of the phantom fiber to mimick muscle fibre activity for the validation of magnetomyography sensors

Ahmet Dogukan Keles¹, Thomas Klotz^1,2, Justus Marquetand³, Oliver Röhrle^1,2

1: Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany; 2: Stuttgart Center for Simulation Sciences (SC SimTech), University of Stuttgart, Stuttgart, Germany; 3: MEG-Center Tübingen, University of Tübingen, Tübingen, Germany

A multiscale network model of tumor microenvironment to predict immunotherapeutic response of head and neck cancers

Priyan Bhattacharya^1,4, Andrew South^2,4, My Mahoney^2,4, Adam Luginbuhl^3,4, Rajanikanth Vadigepalli^1,4

1: Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America; 2: Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America; 3: Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America; 4: Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Mechanobiological modelling to capture relative effects of deviatoric and volumetric stresses on epiphyseal bone growth

Jorge Mateos Arriola¹, Carlos Ruiz Wills¹, Miguel A. González Ballester^1,2, Jérôme Noailly¹

1: Universitat Pompeu Fabra, Spain; 2: ICREA, Spain

Sensory perturbation due to blood flow restriction leads to change in active MU pool

Franziska Bubeck^1,2, Mansour Taleshi³, Ivan Vujaklija³, Oliver Röhrle^1,2, Leonardo Gizzi⁴

1: Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany; 2: Stuttgart Center for Simulation Science, University of Stuttgart, Stuttgart, Germany; 3: Department of Electrical Engineering and Automation, Aalto University, Espoo, Finland; 4: Department of Biomechatronic Systems, Fraunhofer Institute for Manufacturing Engineering and Automation, Stuttgart, Germany

A graphic representation of arterial pulse pressure vs. mean arterial pressure time series may be used for clinical decision support during intraoperative hypotension

Estefanía Žugelj Tapia¹, Marko Žličar², Borut Kirn¹

1: University of Ljubljana, Medical faculty, Ljubljana, Slovenia; 2: University Clinical Centre, Ljubljana, Slovenija

Development of a hemodynamic model to simulate heart failure patients

Juliana Franz^1,2, Arina Borzistaia^1,2, Titus Kühne^1,2, Leonid Goubergrits^1,2

1: Charité - Universitätsmedizin Berlin, Germany; 2: Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany

Hypertensive signature in the photoplethysmography signal by combining a whole-body cardiovascular model and optical simulations

Clement Vasseur, Xavier Bednarek, Pierre Blandin, Matthieu Perriolat, Guillaume Blanquer

Univ. Grenoble Alpes, CEA, LETI, DTIS, Grenoble, France

Pre-procedural planning of transcatheter heart valve interventions using imaging and in silico modelling

Shelly Singh-Gryzbon

University of Cambridge, United Kingdom

A 0D-1D global, closed-loop model of the cardiovascular system

Stefano Costa¹, Lucas Omar Mueller¹, Federica Caforio^2,3,4

1: Dipartimento di Matematica, Università di Trento, (Italy); 2: Department of Mathematics and Scientific Computing, NAWI Graz, University of Graz (Austria); 3: Gottfried Schatz Research Center: Division of Biophysics, Medical University of Graz (Austria); 4: BioTechMed-Graz, (Austria)

In silico validation of TAG-based coronary blood flow distribution methods for patient-specific computational iFR prediction

Ester Bergantin, Lucas Omar Müller

University of Trento, Italy

A comparative study between 3D segmentation methods of aorta in contrast enhanced MR acquisitions

Horia Andrei Leonte^1,2, Alexandru Constantin Serban^1,2, Lucian Mihai Itu^1,2

1: Electrical Engineering and Computer Science, Transilvania University of Brasov, Romania; 2: Advanta, Siemens SRL, Brasov, Romania

Simulation workflow for stent-assisted coiling of brain aneurysms

Felix Borges, Alexander Pugachev

Simq GmbH, Germany

Atmospheric pollutants and atrial arrhythmias: An in silico study

Catalina Tobon¹, Laura C Palacio¹, Sami F Noujaim², Javier Saiz³

1: MATBIOM, Universidad de Medellín, Medellín, Colombia; 2: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, United States; 3: Centro de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, Valencia, Spain

In-silico assessment of hemodynamics in stenoses of the fontan circulation

Adriano Schlief^1,2, Simon Bender^1,2, Peter Kramer^2,3, Marie Schafstedde^1,2,4, Jan Brüning^1,2,4

1: Institute of Computer-assisted Cardiovascular Medicine, Charité – Universitätsmedizin Berlin, Germany; 2: Deutsches Herzzentrum der Charité, Berlin, Germany; 3: Department of Pediatric Cardiology, Charité – Universitätsmedizin Berlin, Germany; 4: DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany

A clinical decision support tool for patient management

Krzysztof Gądek, Adam Nowak, Rafał Niżankowski, Dominik Radziszowski, Joanna Twaróg, Maja Więckiewicz

Sano – Centre for Computational Personalised Medicine International Research Foundation, Poland

Creation and regression analysis of a hemodynamic virtual patient database

Richard Weber, Márta Viharos, Katalin Pálfalvi, Dániel Gyürki, György Paál

Department of Hydrodynamic Systems, Faculty of Mechanical Engineering, Budapest University of Technology and Economics Műegyetem rkp. 3., H-1111 Budapest, Hungary

Towards a prostate cancer radiotherapy digital twin: Simulating the response of prostate cancer to external radiotherapy through mechanistic multiscale modelling. Sensitivity analysis and clinical adaptation

Eleni Kolokotroni A.¹, Foteini Panagiotidou¹, Stamatia Tsampa¹, Christos Kyroudis¹, Simon Spohn^2,3,4, Anca-Ligia Grosu^2,3, Dimos Baltas^3,5, Ilias Sachpazidis^3,5, Constantinos Zamboglou^2,3,6, Georgios S. Stamatakos¹

1: National Technical University of Athens, School of Electrical and Computer Engineering, Institute of Communication and Computer Systems, In Silico Oncology and In Silico Medicine Group, Greece; 2: University of Freiburg, Faculty of Medicine, University Medical Center Freiburg, Department of Radiation Oncology, Germany; 3: German Cancer Consortium (DKTK). Partner Site Freiburg, Germany; 4: Berta-Ottenstein-Programme, Faculty of Medicine, University of Freiburg, Freiburg, Germany; 5: University of Freiburg, Faculty of Medicine, University Medical Center Freiburg, Department of Radiation Oncology, Division of Medical Physics, Germany; 6: German Oncology Center, European University Cyprus, Limassol, Cyprus

Recommendations and requirements for implementing computational models in clinical integrated decision support systems (ISO/TS 9491-2)

Laura Lopez-Perez¹, Elena Martinelli², Marc Kirschner³, Sylvia Krobitsch³, Heike Moser⁴, Giuseppe Fico¹, Tito Poli², Martin Golebiewski⁵

1: Universidad Politécnica de Madrid-Life Supporting Technologies Research Group, ETSIT, 28040 Madrid, Spain; 2: Unit of Maxillofacial Surgery, Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy; 3: Forschungszentrum Jülich GmbH, Projekt Management Jülich, Jülich, Germany; 4: DIN - German Institute for Standardization, Berlin, Germany; 5: Heidelberg Institute for Theoretical Studies (HITS gGmbH), Heidelberg, Germany

Benchmarking computational models of peritoneal dialysis in pigs and patients

Sangita Swapnasrita^1,2, Joost C deVries², Carl Oberg³, Aurelie MF Carlier¹, Karin GF Gerritsen²

1: Maastricht University, the Netherlands; 2: UMC Utrecht, the Netherlands; 3: Lund University, Sweden

Toward multiscale lymph node model: T cell search strategy study

Tomas Bily, Sára Štráchalová, Alžběta Prášilová

CUNI, Czech Republic

Software infrastructure tools for biomedical models in systems biology

Herbert Martin Sauro

University of Washington, United States of America

Probabilistic Boolean modelling highlights neural tube closure dynamics and molecular signalling insights

Ahmed Hemedan¹, Job Berkhout², Luiz Ladeira³, Alessio Gamba³, Harm Heusinkveld², Liesbet Geris^3,4, Bernard Staumont³, Rudi Balling⁵, Marek Ostaszewski^1,6, Venkata Satagopam^1,6, Reinhard Schneider^1,6

1: Luxembourg University, Luxembourg; 2: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; 3: Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Belgium; Skeletal Biology and Engineering Research Center, KU Leuven, Belgium; 4: Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Belgium; 5: Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany; 6: ELIXIR Luxembourg, Belvaux, Luxembourg

Explanatory models of human physiology to teach pathophysiology of diabetic ketoacidosis with simulators

Tomas Kulhanek, Jiri Kofranek

First Faculty of Medicine, Charles University Prague, Czech Republic

In silico clinical trial to predict the efficacy of alendronate for preventing hip fractures

Sophie Nguyen^1,2,3, Sara Oliviero^1,4, Giacomo Savelli^1,4, Antonino Amedeo La Mattina⁴, Marco Viceconti^1,4

1: Department of Industrial Engineering, Alma Mater Studiorum, University of Bologna, Italy; 2: Faculty of Applied Sciences, University of Liège, Belgium; 3: Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Belgium; 4: Medical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

Comparative assessment of lower limb joint angle estimation between BTS system and OpenSim

Mahshida Hamid¹, Sanyam Phutela¹, Rounak Bhattacharyya¹, Manish Gupta², Bhavuk Garg², Rajesh Malhotra^2,3, Madhusudan Pal^4,5, Anoop Chawla¹, Sudipto Mukherjee¹, Kaushik Mukherjee¹

1: Indian Institute of Technology Delhi, India; 2: All Indian Institute of Medical Sciences, New Delhi, India; 3: Indraprastha Apollo Hospital, New Delhi, India; 4: Defense Institute of Physiology & Allied Science, Defence Research & Development Organisation, Delhi, India; 5: Center of Excellence, Footwear Design & Development Institute, Noida, India

Quantification of periprosthetic bone loss using electrical impedance tomography

Lisa Krukewitt, Sascha Spors

University of Rostock, Germany

Machine learning framework to study the impact of metastatic cancer in the spine

Simão Laranjeira¹, Simon Walker-Samuel², Rebecca J. Shipley¹

1: UCL Mechanical Engineering, London, UK; 2: UCL Centre for Computational Medicine, Division of Medicine, London, UK

A sustainable neuromorphic framework for disease diagnosis using AI

Rutwik Gulakala, Marcus Stoffel

RWTH Aachen, Germany

Limits and capabilities of diffusion models for the anatomic editing of digital twins

Karim Kadry¹, Shreya Gupta¹, Farhad R. Nezami², Elazer R. Edelman^1,2

1: MIT, United States of America; 2: Brigham and Women's Hospital

Cross-disease predictive analysis for pandemic preparedness

Joana Elena Meyer¹, Sebastian Fritsch², Andreas Schuppert¹

1: Institute for Computational Biomedicine, RWTH Aachen, Germany; 2: Departement of Intensive Care Medicine, University Hospital RWTH Aachen, Germany