Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
Service anatomy: balancing acute and post-acute Care
Noa Zychlinski1, Itai Gurvich2
1Technion - Israel Institute of Technology; 2Kellogg School of Business, Northwestern University
Motivated by trends in the healthcare industry, we study the integration of Acute Care (AC) and Post-Acute Care (PAC). Patients' outcomes depend on both the AC length of stay and the PAC efforts. A central controller that manages both AC and PAC may choose to discharge a patient earlier and ``compensate'' for this by greater PAC efforts. We characterize the optimal effort integration and its dependencies on patient's operational severity, and the extent to which AC and PAC are complements/substitutes.
Combining pre-Approval clinical trials and post-approval spontaneous adverse event reporting for improved safety signaling
Fernanda Bravo1, Lawrence Chen2, John Silberholz3
1UCLA, United States of America; 2UC Berkeley, United States of America; 3University of Michigan, United States of America
We propose a method to enhance post-approval safety surveillance of pharmaceuticals. Clinical trials typically do not provide sufficient evidence for flagging rare safety issues. Our approach combines pre-approval clinical trial results with post-approval surveillance data for common and rare adverse effects to decide whether to flag the rare reaction, weighing type I and type II error costs. We analytically show when our approach is most valuable and numerically demonstrate its effectiveness.
