Isoprene is a biogenic volatile organic compound with significant relevance in atmospheric chemistry, as it participates in the formation of tropospheric ozone and secondary aerosols. Argentina lacks a detailed inventory of biogenic emissions, as well as continuous measurements of isoprene or volatile organic compounds. This work aims to validate a simulation of isoprene emissions carried out with the MEGAN model for one summer week, using satellite observations of formaldehyde provided by Sentinel-5P. To do this, the spatial coherence between both datasets was mainly analyzed, seeking to verify whether areas with higher modeled isoprene emissions coincide with zones of high formaldehyde concentrations. Consequently, the results show elevated values in the northeast of the country, where vegetation, solar radiation, and temperature favor the emission of volatile organic compounds, especially isoprene. This preliminary analysis helps to evaluate the quality of the simulation and highlights the usefulness of satellite data for studies in locations with scarce field information.