This study evaluates landscape dynamics in the piedmont and escarpment front of the Sierras de Comechingones (San Luis, Argentina) between 1984 and 2025, using remote sensing (Landsat) and landscape metrics to quantify land cover changes and fragmentation patterns. The research addresses two key questions: (1) How has land cover evolved over time (1984, 2005, 2025) at a 1:250,000 scale? and (2) What is the degree of landscape disturbance? The results indicate a significant reduction in native forests (from 35.2% to 17.4%) and an expansion of grasslands (from 19.6% to 48.4%), driven by agricultural intensification, urban sprawl, and recurrent wildfires. Landscape metrics reveal increased fragmentation during the first period (1984–2005), followed by homogenization in the second period (2005–2025), with a decrease in Shannon diversity index values from 1.317 (1984) to 1.413 (2005) and 1.268 (2025), and an increase in the contagion index from 56% (1984) to 48% (2005) and 59% (2025). These metrics suggest a simplification of landscape complexity.The study highlights the role of anthropogenic pressures (agricultural and urban expansion) in transforming the piedmont ecosystem into a more homogeneous scenario, dominated by grasslands and croplands. It underscores the urgent need for integrated landscape planning to mitigate environmental degradation.