Biomass burning in South America contributes to regional aerosol loading, impacting air quality, climate, and public health. Accurate monitoring of AOD during fire events is critical for assessing these impacts. Satellite products such as MODIS-MAIAC offer reliable AOD retrievals but are limited to one or two observations per day. In contrast, the EPIC aboard the DSCOVR/NASA satellite provides near-hourly observations from the L1 Lagrange point, offering new opportunities to capture intra-daily aerosol variability. This study presents an analysis of EPIC-MAIAC AOD over southeastern South America during intense fire seasons in 2020 and 2021. An intercomparison with MODIS-MAIAC was performed. Results show higher values during spring (mean AOD = 0.2) and in known fire hotspots, though retrievals near water surfaces and coastal areas remain uncertain due to surface reflectance challenges. Standard deviation maps support the stability of EPIC retrievals, with low variability (standard deviation between 0 and 0.1) due to temporal averaging across multiple daily observations. Intra-daily analysis of AOD retrieved from EPIC instrument revealed peak values around midday. Time series analysis demonstrates overall agreement between EPIC-MAIAC and MODIS-MAIAC, with EPIC underestimating peak AOD values in some instances. This work highlights EPIC’s potential as a complementary tool for aerosol monitoring during fire events, particularly in capturing short-term fluctuations that are crucial for understanding aerosol transport mechanisms and supporting air quality assessments.