The objective of this paper is to present Political Epistemology as a field that encompasses the works of the Belgian philosopher Isabelle Stengers. Even though the term Political Epistemology includes quite diverse schools of thought, such as historical-dialectic philosophy or Foucaultian archaeology and genealogy, the focus here is to discuss this singular approach and its important repercussions in the field of psychology. To this end, initially we will see how Political Epistemology understands that the invention of modern sciences took place through a rare conjugation of certain powers or potentialities which are able to actualize it. The powers appoint an operator, which is the singular way how human and non-human beings produce testimonies. This is followed by the appropriation of the meaning of this operator in a more generalized interpretation and, finally, we have the potency of this device in connecting interests. The creation of these powers also brings into being as counterparts operations that try to produce scientific knowledge through a methodological recipe ou an a priori concept. Without the risk of the operator, these are considered artifactual productions of science. The latter part of the paper examines how Stengers evaluates the methods of scientific operation of certain well-known psychological schools of thought, such as behaviorism, constructivism, and psychoanalysis.