Nanobody-targeted photodynamic therapy induces systemic antitumor immunity treating local and distant lesions

Irati Beltrán Hernández¹, Tess Uphof², Marcel Fens¹, Henriette de Bruijn³, Dominic Robinson³, Sabrina Oliveira^1,2

¹Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Utrecht, The Netherlands; ²Utrecht University, Faculty of Science, Department of Biology, Utrecht, The Netherlands; ³Erasmus MC Cancer Institute, Department of Otolaryngology and Head & Neck Surgery, Rotterdam, The Netherlands

LUZ51: a low molecular weight carboxamide halogenated bacteriochlorin for the treatment of highly aggressive tumors

Lígia C. Gomes-da-Silva^,, Mafalda Penetra, Bárbara Lima, Claire Donohoe, Luis G. Arnaut

University of Coimbra, CQC-Coimbra Chemistry Center, Portugal

Folate Receptor-Targeted Photodynamic Therapy: A Novel way to Stimulate Anti-tumor Immune Response in Intraperitoneal Ovarian Cancer

Léa Boidin¹, Martha Baydoun¹, Bertrand Leroux¹, Anne-Sophie Vinion-Dewalle¹, Alexandre Quilbe¹, Guillaume Grolez¹, Henry Azaïs², Céline Frochot³, Olivier Morales^1,4, Nadira Delhem¹

¹INSERM, CHU-Lille, U1189-ONCOTHAI-Assisted Laser Therapy and Immunotherapy for Oncology, Univ-Lille, F-59000 Lille, France; ²Assistance Publique des Hôpitaux de Paris (AP-HP), Department of Gynecological and Breast Surgery and Oncology, Pitié-Salpêtrière University Hospital, 75013 Paris, France; ³LGRGP, UMR-CNRS 7274, University of Lorraine, 54 001 Nancy, France; ⁴INSERM UMR9020-UMR-S 1277 – Canther – Cancer Heterogeneity, PlasScity and Resistance to Therapies, F-59000, Lille, France

Evaluation of Photodynamic Therapy Using 5-Aminolevulinic Acid as a New Therapeutic Approach for Nasopharyngeal Carcinoma

Camille Trioën¹, Anthony Lefebvre¹, Anne Sophie Vignion-Dewalle¹, Nadira Delhem¹, Olivier Morales^1,2

¹U1189 ONCOTHAI – Assisted Laser Therapy and Immunotherapy for Oncology-ImmunoPDT and Immunotherapy of Cancer, France; ²INSERM UMR9020 – UMR-S 1277 - Canther – Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, France

Combined photodynamic therapy (PDT) with immunotherapy for difficult-to-treat cancers

Janusz Dabrowski

Jagiellonian University, Poland

Combination of Bremachlorin PDT and immune checkpoint inhibitor anti-PD1 shows sex related survival benefit in murine immunological hot and cold PDAC models

Roisin Mc Morrow^1,2,3, Henriette de Bruijn⁴, Dominic Robinson⁴, Laura Mezzanotte^1,2, Clemens Lowik¹

¹Erasmus Medical Centre, Department of Radiology and Nuclear medicine, Rotterdam, Netherlands; ²Erasmus Medical Centre, Department of Molecular Genetics, Rotterdam, Netherlands; ³Percuros BV, Leiden, Netherlands; ⁴Erasmus MC Cancer Institute, Department of Otorhinolaryngology, Head and Neck surgery, Rotterdam, Netherlands

Toll-like receptors (TLRs) in PDT-induced innate immune response cervical human papillomavirus infection

Maxim Afanasiev¹, Alexander Dushkin², Tatyana Grishacheva³, Oxana Svitich⁴, Polina Kukina⁴, Asmik Avagyan⁴, Alexander Karaulov¹

¹Sechenov University, Russian Federation; ²Moscow City Oncology Hospital 62; ³Pavlov First Saint-Petersburg State Medical University; ⁴Mechnikov Research Institute of Vaccines and Sera

Combination of 5-fluorouracil with photodynamic therapy enhances immune responses in a murine model of actinic keratosis

Sanjay Anand^1,2,3, Cheng-En Cheng¹, Alan Shen³, Edward Maytin^1,2,3

¹Department of Biomedical Engineering, Cleveland Clinic, United States of America; ²Dermatology and Plastic Surgery Institute, Cleveland Clinic, United States of America; ³Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, United States of America