Hypoxic and Normoxic conditions in PDT
Time: Friday, 14/July/2023: 4:45pm - 6:45pm
Session Chair: Angelika Rück
Session Chair: Nikita Durandin
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Location: Small Auditorium
Tampere Hall, 2nd level
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The availability of oxygen during PDT is essential for the induction of phototoxicity. However, hypoxic conditions are often found and involved in tumor development. During PDT, oxygen is also consumed, leading to local hypoxia. Under those conditions, alternatives to TypI/TypII reactions could improve PDT. Within this session, different approaches, leading to novel drugs and techniques, enabling oxygen imaging (for example PLIM) as well as rearranging PDT mechanisms will be discussed.
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Background-free Hypoxia Contrast in Fluorescence Surgical Oncology Imaging with Protoporphyrin IX
Brian Pogue1,2, Arthur Petusseau2, Petr Bruza2, Marien Ochoa1, Matthew Reed1
1Department of Medical Physics, University of Wisconsin-Madison, Madison WI, USA; 2ThayerSchool of Engineering, Dartmouth College, Hanover NH USA
Oxidative damages to chaperone proteins increase selective cytotoxicity to pancreatic cancers
Chae Gyu Lee1, Mingyu Park1, Jeong Soo Kim2, Jihyeon Yang2, Tae-Hyuk Kwon1,2
1Department of Chemistry, Ulsan National Institute of Science and Technology, Korea, Republic of (South Korea); 2O2MEDi incorporation, Ulsan, Republic of Korea
Metabolic NADH/FAD/FMN-FLIM and oxygen PLIM/dFLIM in PDT
Angelika Rück
University Ulm, Germany
Enhancing Biocompatibility of Photosensitizers and Overcoming Hypoxia for Photodynamic Therapy
Chaiheon Lee1, Mingyu Park1, Chae Gyu Lee1, Tae-Hyuk Kwon1,2
1Ulsan National Institute of Science and Technology, Korea, Republic of (South Korea); 2O2MEDI,Korea, Republic of (South Korea)
Disentangling the effects of carbon monoxide and singlet oxygen in photoCORM-based nanomaterials for antimicrobial therapeutics
Valentine Guilbaud1, Corinne Vanucci-Bacqué1, Florence Bedos-Belval1, Tan-Sothea Ouk2, Gautier M. A. Ndong-Ntoutoume2, Frédérique Brégier2, Vincent Sol2, Eric Benoist1, Suzanne Fery-Forgues1
1Université de Toulouse 3, France; 2Université de Limoges, France
Accessing Far-Red Light Induced Photocleavage via Enthropy-Driven Triplet Sensitization For Hypoxia-Targeted, Controlled Cargo Release Applications
Nikita Durandin1, Jussi Isokuortti1, Kaiqi Long2, Omar Al-Saedy1, Weiping Wang2, Timo Laaksonen1,3
1Tampere University, Faculty of Engineering and Natural Sciences, Tampere, Finland; 2The University of Hong Kong, Department of Pharmacology and Pharmacy, Pokfulam, Hong Kong, China; 3University of Helsinki, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Helsinki, Finland
Reactive Oxygen Species Generation Mechanism; Spin-Flip Based Electron Transfer
Tae-Hyuk Kwon1,2, Chae Gyu Lee1
1Ulsan National Institute of Science and Technology, Korea, Republic of (South Korea); 2O2MEDI,Korea, Republic of (South Korea)
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