Remediating Desmoplasia using Targeted Photo-nanomedicines: Improving Surgical and Survival Outcomes

Girgis Obaid¹, Chanda Bhandari¹, Shazia Bano², Kenneth Hoyt¹, Kimberley Samkoe³, Tayyaba Hasan^2,4

¹Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, United States; ²Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, U.S.; ³Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States; ⁴Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, U.S.

Combination of intravesical photodynamic therapy and chemotherapy in intermediate- and high-risk non-muscle invasive bladder cancer: Midterm results from a prospective, multicenter single-arm trial

Jun Tian¹, Linjun Hu², Qingbing Wang³, Zhihong Cao⁴, Jinghua Zeng⁵

¹National Cancer Center, Cancer Hospital Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China, People's Republic of; ²Cancer Hospital of Huanxing Chaoyang District, Department of Urology, Beijing, China.; ³Anyang Cancer Hospital, Department of Surgery, Anyang, China.; ⁴Chinese Academy of Sciences, Hefei Cancer Hospital, Department of Urology, Hefei, China.; ⁵TCM-Integrated Hospital of Southern Medical University, Department of Surgery, Guangzhou, China.

Targeted PDT with an EGFR specific nanobody leads to significant growth delay and cures in a xenograft model

Henriette S. de Bruijn¹, Irati Beltrán Hernández^2,3, Dominic J. Robinson¹, Sabrina Oliveira^2,3

¹Erasmus MC Cancer Institute, Department of Otolaryngology and Head & Neck Surgery, Rotterdam, The Netherlands; ²Utrecht University, Faculty of Science, Department of Biology, Utrecht, The Netherlands; ³Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Utrecht, The Netherlands

A combined modality of photodynamic therapy and Pirarubicin suppresses bladder tumor migration/invasion by inhibiting Smad 2/3 signaling pathway.

Wanru Luo¹, Gongwei Long², Jie Yu³, Huiping Zhang⁴, Jun Tian², Yijun Pang¹

¹Hubei University of Science and Technology,College of Pharmacy,Xianning,China; ²Chinese Academy of Medical Sciences and Peking Union Medical College, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Department of Urology, Shenzhen, China; ³Wuhan Light Industry University,College of Life Sciences,Wuhan,China; ⁴Huazhong University of Science and Technology,Tongji Medical College,Wuhan,China

Preventing and overcoming resistance to PARP inhibitors in cancer cells using photodynamic therapy

Aaron Sorrin¹, Kathryn McNaughton¹, Anika Dasgupta¹, Keri Zhou¹, Cindy Liu¹, Dana Roque^2,3, Huang Chiao Huang^1,3

¹University of Maryland, Fischell Department of Bioengineering, College Park, MD 20742, USA; ²University of Maryland School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Baltimore, MD 21201, USA; ³University of Maryland, Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA

Enabling multi-modal imaging and photoimmunotherapy of oral cancer spheroids through an EGFR-targeted antibody conjugate

Mohammad Saad¹, Stacey Grimaldo-Garcia², Leslie Contreras³, Marvin Xavierselvan⁴, Christopher Nguyen⁴, Allison Sweeney⁴, Scott Selfridge⁵, Robert Pawle⁵, Srivalleesha Mallidi⁴, Tayyaba Hasan^1,6

¹Massachusetts General Hospital, United States of America; ²Middlebury College, Middlebury, United States of America; ³Northeastern University, Boston, United States of America; ⁴Tufts University, Medford, United States of America; ⁵Akita Innovations, North Billerica, United States of America; ⁶Harvard University and Massachusetts Institute of Technology, Cambridge, United States of America

Optimizing theranostic dyes within perfluorocarbon nanoparticles for photodynamic therapy of hypoxic head and neck tumors

Marvin Xavierselvan¹, Brooke Bednarke¹, Jeanne Duong¹, Jason Cook², Srivalleesha Mallidi¹

¹Department of Biomedical Engineering, Tufts University, Medford, MA, USA; ²Nanohybrids Inc, Austin, TX, USA

Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells

Odrun Gederaas^1,2, Animesh Sharma¹, Saide Mbarak¹, Bjørnar Sporsheim^1,4, Anders Høgset⁵, Vanya Bogoeva⁶, Geir Slupphaug^1,3, Lars Hagen^1,3

¹Norwegian University of Science and Technology, NTNU, Trondheim, Norway; ²University of Agder, UiA, Department of Natural Science, Kristiansand, Norway; ³Proteomics and Modomics experimental Core, PROMEC at NTNU and the Central Norway Regional Health Authority, Trondheim, Norway; ⁴CMIC Cellular & Molecular Medicine, NTNU, Norwegian University of Science and Technology, NTNU, and the Central Norway Regional Health Authority, Trondheim, Norway; ⁵PCI Biotech AS, Ullernchaussen 64, 0370 Oslo, Norway; ⁶Institute of Molecular Biology “Roumen Tsaney”, Bulgarian Academy of Science, Department of Molecular Biology and Cell Cycle, 1113 Sofia, Bulgaria