Conference Programme

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AA-04: Nanomaterials for Theranostics-2
Tuesday, 20/Jun/2017:
1:30pm - 3:30pm

Session Chair: Zhuang Liu, Suzhou University
Session Chair: Huiyu Liu, Beijing University of Chemical Technology
Location: Rm 330

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1:30pm - 2:00pm

Nanotechnology for Innovative Cancer Therapies

Zhuang LIU

Soochow University, China (Recipient of 2017 Biomaterials Science Lectureship)

Starting from 2009, our group has been working on the development of functional nanomaterials for applications in biomedical imaging and cancer therapies. In the first part of this talk, I will introduce our latest efforts on the development of nanotechnology to enhance cancer radiation therapy (RT), one of three mainstream cancer treatment methods used in the clinic. We have uncovered that certain types of inorganic nanomaterials could absorb X-ray, acting as radio-sensitizers to enhance the efficacy of RT. With the help of nanotechnology, we could also modulate the tumor microenvironment (e.g. tumor hypoxia) to optimize RT cancer treatment. In the second part, I will then discuss our recent studies in the area of nano-immunotherapy. We have tried to combine photothermal therapy with immunotherapy using multifunctional nano-agents. Stimulated by the tumor-associated antigens released after photothermal tumor ablation, the triggered immunological responses in combination with anti-CTLA4 therapy to suppress the activity of regulatory T cells could result in effective inhibition of tumor cells remaining in the body, promising for treatment of cancer metastasis.

2:00pm - 2:30pm

Lipid-Dendrimer Nanohybrid Systems for the Smart Delivery of Anti-Cancer Drug Combinations

Gigi CHIU, Jinghua DONG, Yanying LEE

Department of Pharmacy, National University of Singapore, Singapore

Developing novel nanohybrids of lipids and hyperbranched polymeric structures called dendrimers has been emerged as an attractive approach in the design of smart drug delivery systems for anti-cancer drugs, including both hydrophobic and hydrophilic agents. In this study, we aim to show the ability of such nanohybrid system in controlling the release of anti-cancer drug combinations that would yield synergistic cancer cell killing effect. The nanohybrids were made from the lipid DPPC and the PAMAM dendrimers in appropriate mole ratios via a sonication step. Paclitaxel (PTX), gemcitabine (GEM) and cisplatin (CIS) was used in this study. Physical characteristics, including size and size distribution, zeta potential, drug encapsulation efficacy, and in vitro drug release in simulated physiological fluids, were determined. Viability of human ovarian cancer cells exposed to various concentrations of the drug-loaded nanohybrids was determined using the MTT viability assay. The combination index was computed to determine if the drug combination was synergistic in anti-cancer activity. The nanohybrids loaded with either PTX/CIS or GEM/CIS drug combination displayed diameters ranging 40-200 nm, depending on the type of dendrimer used. The polydispersity indices reflecting the size distribution were less than 0.50. The encapsulation efficiencies for PTX/CIS or GEM/CIS combinations were more than 70%. The nanohybrids exhibited sequential release of the drug combinations, whereby such release properties could give rise to synergistic anti-cancer cell killing as reflected by the combination indices of less than 1.0. The lipid-dendrimer nanohybrid systems could be useful in the delivery and administration of sequence-dependent anti-cancer drug combinations.

2:30pm - 3:00pm

Photo-induced Cancer Nanotheranostics

Huiyu LIU

Beijing University of Chemical Technology, China

Photo-induced therapy, using light to treat diseases such as cancer and peripheral infections, are very attractive for their minimally invasive as well as localized treatment. So far phototherapy is mainly composed of two modalities, photodynamic therapy and photothermal therapy. With deeper study on the diversely dynamic and heterogeneous features of tumor, there is a growing need to develop more effective photo-induced nanomedicine. In this report, some classes of near infrared absorbing inorganic phototherapy agents with attractive physico-chemistry properties will be presented, such as novel metal nanomaterials, semiconductor nanomaterials and carbon-based nanomaterials. Also, a comparison study of clinical intervention therapy with the interventional photothermal therapy in an orthotopic xenograft model of human pancreatic cancer was illustrated here. We believe these studies will have a positive impact on the future clinical translation of plasmonic nanoparticles.

3:00pm - 3:15pm

Aptamer-AIE Dots: A Promising Tumor-Targeting Nanoprobe for Translational Medicine

Pengfei ZHANG1,2, Zheng ZHAO1, Chuansheng LI2, Huifang SU1,3, Yayun WU2, Tsz Kin KWOK1, Jacky Wing Yip LAM1, Ping GONG2, Lintao CAI2, Ben Zhong TANG1

1Hong Kong University of Science and Technology, Hong Kong S.A.R. (China); 2Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China; 3Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, China

We developed a facile and simple one-step method to fabricate aptamer-targeting organic dots with aggregation induced emission based on self-assembling method. As-prepared aptamer AIE-dots, which integrated the advantages of AIEgens with the cell-targeting capabilities of aptamers, showed specific targeting ability, highly stability, and good biocompatibility. Based on this general method, a variety of biocompatible highly bright organic fluorescent nanoprobes with specific recognition and highly sensitivity could be facilely constructed for long-term, real-time sensing and biomedical imaging.

3:15pm - 3:30pm

Synthesis of Rare Sugar Functionalized Graphene Oxide

Toru MIZUKI1,2, Keisuke HIRATA2, Takashi UCHIDA1,2, Yoshikata NAKAJIMA1,2, Toru MAEKAWA1,2

1Bio-Nano Electronics Research Centre, Toyo University, Japan; 2Graduate School of Interdisciplinary New Science, Toyo University, Japan

Recently, graphene and graphene oxide (GO) has researched to apply for field of biology as scaffolding of culture and function materials, and reported that biocompatibility vary greatly depending on surface modification.

Reduced graphene oxide (RGO) has intermediate functions between graphene and GO, such as high conductivity, easily chemical modification, and great biocompatibility. RGO has been applied for biosensor, cancer therapy, and organic solar cell. Common methods of reduction of GO are exposure treatment with hydrazine hydrate or heat treatment with electric furnace. However, the methods carry a lot of risk, so that green approaches are suggested for more safety and more ecological process. This study, we aim to synthesis rare sugar functionalized graphene oxide (RSfGO) by reducing GO using rare sugars that, is known as useful sugar, have many unique functions such as antioxidant action, inhibition of cancer cell growth, and function of control sugar level in the blood.

In this study, we attempted to reduce GO using some kinds of rare sugars that are little monosaccharide in nature. We mixed GO solution and rare sugars, and boiled it. After centrifuging, we washed precipitate with pure water for three times.

We analyzed surface of prepared samples using Raman spectroscopy, x-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible absorption spectroscopy (UV-vis), and scanning electron microscope (SEM). Accordingly, G/D ratio of Raman spectrum graph and transition of absorbance spectrum of UV-vis suggested reduction of GO. We should obtain RSfGO that are created by reduction and modification of GO using rare sugars.

We analyzed cytotoxicity of the products with red blood cell (from sheep), bacteria (Escherichia coli JM 109 and Bacillus subtilis JCM1465) and human multiple myeloma cell (IM-9). It have been shown that RSfGO inhibited growth of E.coli and IM-9 cell.

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