1:30pm - 2:00pmInvited
Nanostructured Biomaterials for Medical and Biological Applications
Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR), Singapore
Nanostructured materials have been developed for various medical and biological applications. They have been designed as stimuli-responsive drug delivery systems and sustained protein delivery systems. Nanocomposite systems have also been derived to provide simultaneous drug delivery and bioimaging functions as theranostic systems. Micellar nanocomplexes have been synthesized with green tea-based ingredients as unique carrier materials that offer synergistic therapeutic effects with the drugs to be delivered.
In addition, nanostructure processing has been employed in creating synthetic cell culture substrates for the expansion and controlled differentiation of stem cells. Nanostructured scaffolds have also been obtained for cell and tissue engineering. Unique hydrogels have been developed for antifouling biomaterial applications.
2:00pm - 2:30pmInvited
Engineered Nanomaterials for Diagnostics and Therapy
Nature Biomedical Engineering, United States
The need to visualize molecules, cells and tissues puts imaging techniques centre stage in biomedical research. Biomedical scientists and engineers working on nanomaterials for translational medicine also take advantage of knowledge that cuts across tissue engineering, materials science and regenerative medicine. Those devising better approaches to deliver immunotherapeutic drugs need to integrate concepts from cancer immunotherapy and nanotechnology. Researchers aiming to help surgeons make informed decisions faster and more accurately are drawing on techniques from artificial intelligence and on the knowledge of the pathologist. For creative minds with problem-solving skills methods and approaches from the physical, biological and medical sciences can offer a fruitful playground at junctures between neuroscience and machine/brain interfaces, nanotechnology and biotechnology, and therapy and diagnostics. In this talk, the Chief Editor of Nature Biomedical Engineering will highlight the latest research at the convergence of fields in the health and materials sciences and nanotechnology.
2:30pm - 2:45pmOral
Cornell Dots: Fluorescent Nanoparticles Translated Into The Clinic
Cornell University, United States
Despite significant promise of nanomaterials in medicine, few colloidal materials make the transition into the realm of human clinical applications. In this presentation a novel class of multifunctional fluorescent silica-based core-shell nanoparticles will be introduced referred to as “Cornell dots” or simply “C dots”. These particles have sizes below 10 nm, which is below the threshold for renal clearance, leading to favorable biodistributions and pharmacokinetics. These smaller than 10 nm sized PEGylated labels for nanomedicine are the first dual-modality (optical/PET) hybrid nanoparticles of their class and properties receiving investigational new drug (IND) FDA approval for first in-human clinical trials in the US. In this presentation, results on C dot synthesis, characterization, and optical properties will be discussed with focus on materials properties that facilitate transition into clinical applications. First results will then be reported on clinical trials with human melanoma patients assessing particle safety. Subsequently, work towards employing these probes in sentinel lymph node (SLN) mapping will be described. The talk will conclude with results on C dots as novel cancer therapeutic agents.
 S. Eun Kim, L. Zhang, K. Ma, M. Riegman, F. Chen, I. Ingold, M. Conrad, M. Z. Turker, M. Gao,X. Jiang, S. Monette, M. Pauliah, M. Gonen, P. Zanzonico, T. Quinn, U. Wiesner, M. S. Bradbury, M. Overholtzer, Ultrasmall Nanoparticles Induce Ferroptosis in Nutrient-Deprived Cancer Cells and Suppress Tumor Growth, Nat. Nanotech. 11 (2016), 977–985.
 E. Phillips, O. Penate-Medina, P. B. Zanzonico, R. D. Carvajal, P. Mohan, Y. Ye, J. Humm, M. Gönen, H. Kaliagian, H. Schöder, H. W. Strauss, S. M. Larson, U. Wiesner, M. S. Bradbury, Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe, Sci. Transl. Med. 6 (2014), 260ra149.
3:00pm - 3:15pmOral
Effects of Surface Substituents on Electronic Structures of a Cerasome Model
Wakayama University, Japan
Recently, Drug Delivery Systems (DDSs) have attracted much attention. Its main aim is to reduce undesirable side effects in drug therapy. The construction of the DDS requires a technology to encapsule a drug and to release it around the diseased area. Lipid bilayer vesicles, so-called liposomes, are typical DDS materials. However, liposomes do not have enough stability because all the lipids are connected via van der Waals interactions. As a result of this low stability, liposomes cannot reach the diseased part intact. To overcome this problem, cerasomes have been developed, i.e., liposomes featuring surfaces reinforced with a siloxane bond network. It has been shown that a cerasome can encapsule a drug and is much more stable than a liposome. Thus, cerasomes are promising materials for DDS. Although there is lots of research for application, basic properties of the cerasome such as microscopic structures and electronic states have not been cleared yet. In the previous work, we construct a simple cerasome model to investigate the electronic structures of its surface. Comparing the electronic structures of the membrane model with that of the molecule, we reveal that there are mid-gap states in the membrane model that are not in the molecule. These mid-gap states originate from antibonding states of Si-C bonds that connect the siloxane network and organic parts of the lipid. However, the model is extremely simple, we assume perfect siloxane network, although there are many O- and OH groups on the surface of actual cerasomes. The purpose of this study is to investigate the effect of surface substituent groups on the electronic structure of the cerasome model.
 S. Yabushita, at. al., e-JSSNT 12, 112, 2014.