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Program Overview
Session
Distinguished Investigator Award: Andrew Holmes
Time:
Thursday, 06/June/2024:
4:45pm

Virtual location: AHB 1R40


Dr. Winona Booher (postdoc Univ Colorado) will be introducing Dr. Andrew Holmes.

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Presentations

Mechanisms supporting neural representations of memory

Andrew Holmes

NIH

Brain systems mediating responses to previously encountered threats are critical to animals’ survival. This presentation will discuss how learned threats generate neural representations of fear state in the basolateral amygdala (BLA), and present novel evidence for the contribution of non-neuronal cells to this process. The talk will cover techniques including in vivo calcium (Ca2+) imaging, optogenetics and chemogenetics to demonstrate how BLA cells track fear state and causally contribute to cued fear memory retrieval. The findings presented will reveal a key role for both neuronal and non-neuronal cells in memory retrieval via modulation of amygdala neural representation of fear state, revising current neurocentric models of an essential survival function.