Conference Agenda
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Poster Size: Posters need to be portrait and no more than A0 size (841mm (w) x 1189 mm (h) or 33.1 inches (w) x 46.8 inches (h)).
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Program Overview |
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Early Career Achievement Award: Dr. Francesca Telese
Dr. Hayley Thorpe (postdoc Western, Salk) will be introducing Dr. Francesca Telese | ||
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Gene Regulatory Mechanism Shaping Brain Function and Dysfunction University of California San Diego Francesca Telese The dynamic regulatory landscape of the brain plays a crucial role in shaping its development, cellular complexity, and susceptibility to diseases, emphasizing the importance of studying psychiatric disorders in a temporal- and cell-type-specific fashion. Central to understanding how gene regulatory networks control brain functions are distal genomic enhancer elements that control the activity of diverse brain cells in a spatiotemporal manner. The linkage between enhancers and disease vulnerability is underscored by findings that single nucleotide polymorphisms (SNPs) associated with psychiatric disorders are enriched in these enhancer regions. Such SNPs likely interfere with enhancer function and their interaction with transcription factors, altering gene expression and leading to disease. My research employs genomic technologies to explore gene regulatory mechanisms that underpin both normal brain function and disease mechanisms. I have identified epigenetic processes crucial for activity-dependent gene transcription in neurons, including the role of Reelin-dependent enhancers and LSD1-dependent histone demethylation in learning and memory. Furthermore, I have delineated cell type-specific gene regulatory networks that play a role in substance use disorders across various brain regions. Recently, I have focused on assessing the impact of genetic variants on regulatory functions through advanced transcriptomic approaches, including transcriptional initiation profiling and massive parallel reporter assays. I will present data showing how my work has identified cell-type-specific transcriptional and regulatory mechanisms associated with shaping brain function and dysfunction. Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, US Funding Support: NIDA R21DA056177, U01DA051972, U01DA050239, R01DA056602, DP1DA042232 | ||
