The formal scientific method tells you how to rigorously and objectively test a hypothesis. But where do hypotheses come from in the first place? Posing fruitful new questions, generating ideas for novel hypotheses, and devising innovative experimental technologies all require scientific creativity. Compared to the executive “day science” process, the creative “Night Science” process requires a different mindset. It builds on a different set of thinking tools, such as an open mindset, anthropomorphic language, embracing contradictions, and importing ideas across fields.