An aspect of the indigenous struggle against colonial oppression is the struggle for the inclusion of their knowledge in policymaking. Perceived as epistemically inferior to science, indigenous knowledge and thus interests are systematically excluded in science-based policy. This article advances an anti-colonial political philosophy of science. As indigenous knowledge feeds into the necessary political value judgements in policy-relevant science, indigenous knowledge inclusion, I contend, should be treated as a political, not solely epistemic, matter. I further argue that indigenous peoples, not just scientists, should have the power to make such political value judgements given the politics of representation under coloniality.