EUROMIT 2023 - International Meeting on Mitochondrial Pathology

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Session

Session 4.3: Therapy 3: reproductive options and mtDNA editing

Time:

Wednesday, 14/June/2023:

1:15pm - 2:45pm

Session Chair: Carlo Viscomi
Session Chair: Daniela Zuccarello

Location: Bologna Congress Center - Sala Europa

Address: Piazza della Costituzione, 4/a, Bologna (BO), Italy

Invited Speaker: M. Herbert; M. Minczuk

Presentations

Invited

Mitochondrial replacement in action

Mary Herbert^1,2, Louise Hyslop², Yuko Takeda¹, Magomet Aushev¹, Meenakshi Choudhary², Jane Stewart²

¹Newcastle University, United Kingdom; ²Newcastle Fertility Centre

Invited

The therapeutic potential of mitochondrial genome engineering

Michal Minczuk

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Oral presentation

MitoKO: A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome

Pedro Silva-Pinheiro, Christian D. Mutti, Lindsey Van Haute, Christopher A. Powell, Pavel A. Nash, Keira Turner, Michal Minczuk

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Oral presentation

Risk of mtDNA reversal among children born after mitochondrial replacement therapy

Shoukhrat Mitalipov¹, Nuria Marti Gutierrez²

¹Oregon Health & Science University, United States of America; ²Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, United States of America

Flash Talk

Specific elimination of m.3243A>G mutant mitochondria DNA using mitoARCUS

Wendy K. Shoop^1,2, Cassandra L. Gorsuch¹, Emma Sevigny¹, Sandra R. Bacman², Janel Lape¹, Jeff Smith¹, Derek Jantz¹, Carlos T. Moraes²

¹Precision BioSciences - Durham, NC, United States of America; ²University of Miami - Miami, FL, United States of America

Flash Talk

MitoCRISPR/Cas9 shifts mtDNA heteroplasmy not as effective as other site-specific nucleases.

Elvira Zakirova^1,2, Ilya Mazunin³, Elena Kiseleva², Ksenia Morozova^1,2, Konstantin Orishchenko^1,2

¹Novosibirsk State University, Novosibirsk, Russia; ²Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; ³Skolkovo Institute of Science and Technology, Moscow, Russia

Flash Talk

Prenatal diagnostics for a family with 13513G>A mtDNA mutation associated with Leigh Syndrome

Crystal M Van Dyken¹, Amy Koski¹, Hong Ma¹, Nuria Marti Gutierrez¹, Aleksei Mikhalchenko¹, Rebecca Tippner-Hedges¹, Daniel Frana¹, Paula Amato², Shoukhrat Mitalipov¹

¹Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, United States of America; ²Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health and Science University, United States of America

Conference Agenda