Conference Agenda

Transcriptional regulation of mitochondrial stress responses

Aleksandra Trifunovic

University of Cologne, Germany

Mitochondrial DNA mutations in ageing and cancer - what's the connection?

Anna Smith¹, Julia Whitehall¹, Shivam Karadkar¹, Pedro Silva-Pinheiro², Conor Lawless¹, Michal Minczuk², Doug Turnbull¹, Owen Sansom³, Laura Greaves¹

¹Wellcome Centre for Mitochondrial Research, Newcastle University, United Kingdom; ²MRC Mitochondrial Biology Unit, Cambridge, United Kingdom; ³CRUK Beatson Institute, Glasgow, United Kingdom

Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria

Janne Purhonen^1,2, Rishi Banerjee^1,2, Vilma Wanne^1,2, Nina Sipari³, Matthias Mörgelin^4,5, Vineta Fellman^1,2,6,7, Jukka Kallijärvi^1,2

¹Folkhälsan Research Center, Finland; ²Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Finland; ³Viikki Metabolomics Unit, University of Helsinki, Finland; ⁴Division of Infection Medicine, Department of Clinical Sciences, Lund University, Sweden; ⁵Colzyx AB, Lund, Sweden; ⁶Department of Clinical Sciences, Lund, Pediatrics, Lund University, Sweden; ⁷Children’s Hospital, Helsinki University Hospital, Finland

A genetic deficiency screen in vivo reveals rescue mechanisms of mitochondrial dysfunction

Najla El Fissi¹, Florian Rosenberger², Kai Chang¹, Thomas Benedict Barton-Owen³, Zoe Golder³, Matthias Mann², Patrick Chinnery³, Anna Wedell¹, Christoph Freyer¹, Anna Wredenberg¹

¹Karolinska Institutet, Sweden; ²Max-Planck Institute of Biochemistry, Germany; ³University of Cambridge, Cambridge Biomedical Campus, UK

Heterochromatin Protein 1 controls gene expression and longevity in response to mitochondrial dysfunction

Patricia de la Cruz Ruiz¹, Hayat Heluani Gahete^1,2, María de los Angeles Ortega De La Torre², María Jesús Rodríguez Palero^1,2, Cristina Ayuso García¹, Shinya Ohta³, Peter Askjaer¹, Marta Artal-Sanz^1,2

¹Andalusian Centre for Developmental Biology (CABD). CSIC-Universidad Pablo de Olavide-Junta de Andalucía. Carretera de Utrera Km 1, 41013 Sevilla, Spain.; ²Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide. Carretera de Utrera Km 1, 41013 Seville, Spain; ³Department of Biochemistry, Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan.

High fat diet ameliorates the mitochondrial cardiomyopathy of CHCHD10 mutant mice

Hibiki Kawamata, Nneka Southwell, Nicole Sayles, Giovanni Manfredi

Weill Cornell Medicine, United States of America

Functional characterisation of the human mitochondrial disaggregase, CLPB

Megan J Baker¹, Alexander J Anderson¹, Catherine S Palmer¹, David R Thorburn^2,3, Ann E Frazier², Diana Stojanovski¹

¹Department of Biochemistry and Pharmacology, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville VIC 3010, Australia; ²Murdoch Children’s Research Institute, Royal Children’s Hospital and Department of Paediatrics, The University of Melbourne, Parkville VIC 3052, Australia; ³Victorian Clinical Genetics Services, Royal Children’s Hospital, Melbourne, Parkville VIC 3052, Australia

The mitochondrial inhibitor IF1 has a dual role in cancer

Martina Grandi¹, Cristina Gatto¹, Simone Fabbian², Natascia Tiso³, Francesco Argenton³, Massimo Bellanda², Giancarlo Solaini¹, Valentina Giorgio*¹, Alessandra Baracca*¹

¹Department of Biomedical and Neuromotor Sciences, University of Bologna; ²Department of Chemical Science, University of Padova; ³Department of Biology, University of Padova, Padova