Time: Tuesday, 13/June/2023: 1:45pm - 3:30pm Session Chair: Luca Scorrano Session Chair: Luisa Iommarini |
Location: Bologna Congress Center - Sala Europa Address: Piazza della Costituzione, 4/a, Bologna (BO), Italy |
ID: 195
Metabolic stress responses in mitochondrial diseases, ageing and cancer
Transcriptional regulation of mitochondrial stress responses
University of Cologne, Germany
1.Croon M, Szczepanowska K, Popovic M, Lienkamp C, Senft K, Brandscheid CP, Theresa Bock T, Gnatzy-Feik L, Ashurov A, Acton RA, Kaul H, Pujol C, Rosenkranz S, Krüger M and Trifunovic A. (2022) FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction. Sci Adv. 2022 Apr 8;8(14):eabn7105.
2.Rumyantseva A, Popovic M and Trifunovic A. (2022) CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain Feb 11;e109169.
3.Kaspar, S., Oertlin, C., Szczepanowska, K., Kukat, A., Senft, K., Lucas, C., Brodesser, S., Hatzoglou, M., Larsson, O., Topisirovic, I., Trifunovic, A. (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci. Adv. 7, eabf0971
ID: 678
Invited Speakers
Mitochondrial DNA mutations in ageing and cancer - what's the connection?
1Wellcome Centre for Mitochondrial Research, Newcastle University, United Kingdom; 2MRC Mitochondrial Biology Unit, Cambridge, United Kingdom; 3CRUK Beatson Institute, Glasgow, United Kingdom
Gorelick, A. N., M. Kim, W. K. Chatila, K. La, A. A. Hakimi, M. F. Berger, B. S. Taylor, P. A. Gammage and E. Reznik (2021). "Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA." Nat Metab 3(4): 558-570.
Greaves, L. C., M. J. Barron, S. Plusa, T. B. Kirkwood, J. C. Mathers, R. W. Taylor and D. M. Turnbull (2010). "Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts." Exp Gerontol 45(7-8): 573-579.
Smith, A. L. M., J. C. Whitehall, C. Bradshaw, D. Gay, F. Robertson, A. P. Blain, G. Hudson, A. Pyle, D. Houghton, M. J. Hunt, J. N. Sampson, C. Stamp, G. Mallett, S. Amarnath, J. Leslie, F. Oakley, L. Wilson, A. Baker, O. M. Russell, R. Johnson, C. A. Richardson, B. Gupta, I. McCallum, S. A. C. McDonald, S. Kelly, J. C. Mathers, R. Heer, R. W. Taylor, N. D. Perkins, D. M. Turnbull, O. J. Sansom and L. C. Greaves (2020). "Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis." Nature Cancer 1(10): 976-989.
ID: 452
Metabolic stress responses in mitochondrial diseases, ageing and cancer
Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria
1Folkhälsan Research Center, Finland; 2Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Finland; 3Viikki Metabolomics Unit, University of Helsinki, Finland; 4Division of Infection Medicine, Department of Clinical Sciences, Lund University, Sweden; 5Colzyx AB, Lund, Sweden; 6Department of Clinical Sciences, Lund, Pediatrics, Lund University, Sweden; 7Children’s Hospital, Helsinki University Hospital, Finland
Purhonen J., Banerjee R, Wanne V. Sipari N. Mörgelin M. Fellman V. and Kallijärvi J. Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria. BioRxiv 2023; 01.10.521980.
Purhonen J. and Kallijärvi J. Quantification of all 12 canonical ribonucleotides by real-time fluorogenic in vitro transcription. BioRxiv 2023; 02.18.527797.
Banerjee R. Purhonen J. and Kallijärvi, J. The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology. The FEBS Journal 2021; 289, 6936–6958.
Purhonen J, Banerjee R, McDonald AE, Fellman V, Kallijärvi J. A sensitive assay for dNTPs based on long synthetic oligonucleotides, EvaGreen dye, and inhibitor-resistant high-fidelity DNA polymerase. Nucleic Acids Research 2020: gkaa516
Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J. A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nature Communications 2020;11:1–12.
Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner J, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J. Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Molecular Medicine 2019;11:e9456.
ID: 624
Metabolic stress responses in mitochondrial diseases, ageing and cancer
A genetic deficiency screen in vivo reveals rescue mechanisms of mitochondrial dysfunction
1Karolinska Institutet, Sweden; 2Max-Planck Institute of Biochemistry, Germany; 3University of Cambridge, Cambridge Biomedical Campus, UK
ID: 456
Metabolic stress responses in mitochondrial diseases, ageing and cancer
Heterochromatin Protein 1 controls gene expression and longevity in response to mitochondrial dysfunction
1Andalusian Centre for Developmental Biology (CABD). CSIC-Universidad Pablo de Olavide-Junta de Andalucía. Carretera de Utrera Km 1, 41013 Sevilla, Spain.; 2Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide. Carretera de Utrera Km 1, 41013 Seville, Spain; 3Department of Biochemistry, Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan.
ID: 381
Metabolic stress responses in mitochondrial diseases, ageing and cancer
High fat diet ameliorates the mitochondrial cardiomyopathy of CHCHD10 mutant mice
Weill Cornell Medicine, United States of America
ID: 413
Metabolic stress responses in mitochondrial diseases, ageing and cancer
Functional characterisation of the human mitochondrial disaggregase, CLPB
1Department of Biochemistry and Pharmacology, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville VIC 3010, Australia; 2Murdoch Children’s Research Institute, Royal Children’s Hospital and Department of Paediatrics, The University of Melbourne, Parkville VIC 3052, Australia; 3Victorian Clinical Genetics Services, Royal Children’s Hospital, Melbourne, Parkville VIC 3052, Australia
ID: 448
Metabolic stress responses in mitochondrial diseases, ageing and cancer
The mitochondrial inhibitor IF1 has a dual role in cancer
1Department of Biomedical and Neuromotor Sciences, University of Bologna; 2Department of Chemical Science, University of Padova; 3Department of Biology, University of Padova, Padova
1. Galber, C; Fabbian, S; Gatto, C; Grandi, M; Carissimi, S; Acosta, MJ; Sgarbi, G; Tiso, N; Argenton, F; Solaini, G; Baracca, A; Bellanda, M; Giorgio,CELL DEATH & DISEASE, 2023, 14, pp. 1 - 19
2. Gatto, C; Grandi, M; Solaini, G; Baracca, A; Giorgio, V, FRONTIERS IN PHYSIOLOGY, 2022, 13, 917203, pp. 1 - 11
3. Galber C; Minervini G; Cannino G; Boldrin F; Petronilli V; Tosatto S; Lippe G; Giorgio V, CELL REPORTS, 2021, 35, 109111, pp. 1 - 14