Conference Agenda

Fuels and drivers of smouldering brain disease

Stefano Pluchino, Luca Peruzzotti-Jametti, Alexandra Nicaise

University of Cambridge, United Kingdom

Immunometabolisms at the crossroad between inflammation and aging

Maria Mittelbrunn

CSIC- Consejo Superior de Investigaciones Cientificas, Spain

Dissecting the role of type I interferon signaling in microglial response in a mouse model of mitochondrial disease

Melania González-Torres^1,2, Patrizia Bianchi¹, Patricia Prada-Dacasa¹, Joaquín Fernández-Irigoyen³, Enrique Santamaría³, Mariona Arberola⁴, Elisenda Sanz^1,2, Albert Quintana^1,2

¹Institute of Neurosciences, Autonomous University of Barcelona, Barcelona, Spain; ²Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, Barcelona, Spain; ³Clinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Pamplona, Spain; ⁴Centro de Análisis Genómico, CNAG-CRG, Barcelona, Spain

The contribution of cell free-mitochondrial DNA in the pathogenesis of MELAS syndrome

Alessandra Maresca¹, Monica Moresco¹, Valentina Del Dotto², Concetta Valentina Tropeano¹, Mariantonietta Capristo¹, Claudio Fiorini¹, Danara Ormanbekova¹, Alessandro Rapone², Maria Lucia Valentino^1,2, Chiara La Morgia^1,2, Valerio Carelli^1,2

¹IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Italy; ²Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy

A novel role for the mitochondrial topoisomerase TOP1MT in mediating mtDNA release and cGAS-STING activation

Iman Al Khatib¹, Yves Pommier², Phillip West³, William Gibson⁴, Tim Shutt¹

¹University of Calgary, Canada; ²National Institutes of Health; ³Texas A&M University; ⁴University of British Columbia

Impaired inflammatory response to lipopolysaccharide in fibroblasts from patients with long-chain fatty acid oxidation disorders

Signe Mosegaard^1,2, Krishna Twayana³, Simone Denis¹, Jeffrey Kroon⁴, Bauke Schomakers⁵, Michel van Weeghel⁵, Riekelt Houtkooper¹, Rikke Olsen², Christian Holm³

¹Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; ²Research Unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; ³Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, Denmark; ⁴Department of Experimental Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; ⁵Core Facility Metabolomics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

Fumarate induces mtDNA release via mitochondrial-derived vesicles and drives innate immunity

Vincent Paupe¹, Vincent Zecchini², Christian Frezza^2,3, Julien Prudent¹

¹Medical Research Council, MBU,University of Cambridge, UK; ²Medical Research Council Cancer Unit,University of Cambridge, UK; ³CECAD Research Centre, University of Cologne, Cologne, Germany

Free cytosolic-mitochondrial DNA triggers a potent type-I Interferon response in Kearns–Sayre patients counteracted by mofetil mycophenolate

Michela Di Nottia¹, Ivan Caiello², Alessandra Torraco¹, Martina Zoccola¹, Fabrizio De Benedetti², Carlo Dionisi-Vici³, Enrico Bertini⁴, Diego Martinelli³, Rosalba Carrozzo¹

¹Unit of Cellular Biology and Diagnosis of Mitochondrial Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ²Division of Rheumatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; ³Division of Metabolism, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; ⁴Research Unit of Muscular and Neurodegenerative Disorders, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy