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Session Overview |
Session | ||
Session 2.4: New technological developments and OMICS
Invited Speaker: :S. Churchman; :H. Hillen
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Presentations | ||
Invited
ID: 683 Invited Speakers Decoding the regulatory principles of mitochondrial DNA: packaging, expression, and impact on cellular metabolism Harvard Medical School, United States of America Invited
ID: 705 Invited Speakers Mechanisms of mitochondrial RNA biogenesis in health and disease 1Department of Cellular Biochemistry, University Medical Center Göttingen, Germany; 2Research Group Structure and Function of Molecular Machines, Max-Planck-Institute for Multidisciplinary Sciences Göttingen, Germany Bibliography
Bhatta A, Dienemann C, Cramer P, Hillen HS (2021) Structural basis of RNA processing by human mitochondrial RNase P. Nature Structural & Molecular Biology 28, 713-723. Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson N-G (2020) Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588, 712-716 Hillen HS, Temiakov D, Cramer P (2018) Structural basis of mitochondrial transcription. Nature Structural & Molecular Biology 25, 754–765 Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D (2017) Mechanism of Transcription Anti-termination in Human Mitochondria. Cell 171, 1082-1093.e13 Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P (2017) Structural Basis of Mitochondrial Transcription Initiation. Cell 171, 1072-1081.e10 Oral presentation
ID: 338 New technological developments and OMICS Disruption of mitochondrial function induces cell lineage-specific compensatory transcriptional responses during early embryonic development 1Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK; 2Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK; 3Novo Nordisk Research Centre Oxford, Innovation Building, University of Oxford, Old Road Campus, Oxford, UK; 4Functional Genomics Centre, Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK; 5Department of Medical Biochemistry and Cell Biology, University of Gothenburg, PO Box 440, Gothenburg 405 30, Sweden; 6Max Planck Institute for Biology of Ageing, Cologne, Germany; 7Biosciences Institute, Faculty of Medical Sciences, Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK Bibliography
1. Burr et al., Cell, 2023, DOI: 10.1016/j.cell.2023.01.034 Oral presentation
ID: 120 New technological developments and OMICS Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cells 1Department of Pathology, Stanford University, Stanford, CA 94305, USA; 2Parker Institute of Cancer Immunotherapy, San Francisco, CA 94129, USA; 3Department of Genetics, Stanford University, Stanford, CA 94305, USA; 4Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; 5Division of Hematology / Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; 6Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; 7Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), 10115 Berlin, Germany; 8Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany; 9Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Berlin, Germany; 10Technology Innovation Lab, New York Genome Center, New York, NY 10013, USA; 11Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134, USA; 12Center for Pediatric Neurosciences, Mitochondrial Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; 13Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA; 14Department of Pediatric Oncology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, 13353 Berlin, Germany; 15Department of Computer Science, Stanford University, Stanford, CA 94305, USA; 16Department of Biology and Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; 17Current address: Immunai, New York, NY 10114, USA; 18Current address: 10x Genomics, San Francisco, CA 94111, USA; 19Current address: Genentech, San Francisco, CA 94080, USA Bibliography
Preprint of the manuscript: https://www.biorxiv.org/content/10.1101/2022.11.20.517242v1 Related prior work: https://www.nejm.org/doi/full/10.1056/NEJMoa2001265 https://www.nature.com/articles/s41587-020-0645-6 https://www.nature.com/articles/s41587-021-00927-2 Flash Talk
ID: 125 New technological developments and OMICS Quantifying mitochondrial proteome remodeling during macrophage polarization University of Lausanne, Switzerland Bibliography
1. C. L. Strelko, et al. J Am Chem Soc. 2011, 133, 16386-16389 2. A. K. Jha, et al. Immunity. 2015, 42, 419-430 3. P. S. Liu, et al. Nat Immunol. 2017, 18, 985-994 4. D. Vats, et al. Cell Metab. 2006, 4, 13-24 5. S. Rath, et al. Nucleic Acids Res. 2021, 49, D1541-D1547 6. A. Michelucci, et al. Proc Natl Acad Sci U S A. 2013, 110, 7820-7825 7. Z. Zhong, et al. Nature. 2018, 560, 198-203 8. S. A. Clayton, et al. Sci Adv. 2021, 7, eabl5182 Flash Talk
ID: 374 New technological developments and OMICS Quantification of all 12 canonical ribonucleotides by real-time fluorogenic in vitro transcription 1Folkhalsan Research Center, Finland; 2Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki Bibliography
1. Banerjee R, Purhonen J, Kallijärvi J. The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology. FEBS J (2021) 2. Purhonen J, Banerjee R, McDonald AE, Fellman V, Kallijärvi J. A sensitive assay for dNTPs based on long synthetic oligonucleotides, EvaGreen dye and inhibitor-resistant high-fidelity DNA polymerase. Nucleic Acids Res 48(15), e87 (2020) 3. Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J. A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322 (2020) Flash Talk
ID: 356 New technological developments and OMICS Long-read NGS for detection of mitochondrial DNA large-scale deletions and complex rearrangements 1Fondazione IRCCS Istituto Neurologico Carlo Besta (Milan, Italy); 2University of Milan (Milan, Italy) |