Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

 
Session Overview
Date: Sunday, 25/Mar/2018
1:15pm
-
5:30pm
Tutorium: Modeling Discrete Time-to-Event Data
Location: H22-2 Lecture Hall
Moritz Berger, Matthias Schmid, Thomas Welchowski
Tutorium: Eine Einführung in die Versorgungsforschung für Biostatistiker
Location: S22-1 Seminar Room
Freia De Bock, Jochem König, Irene Schmidtmann
Vorstand- und Beiratssitzung IBS-DR (14:30-17:30)
Location: S20-6 Seminar Room
6:00pm
-
7:30pm
ÖV: Zu Risiken und Nebenwirkungen fragen Sie Ihre Ärztin und Ihren Statistiker
Location: H20-5 Lecture Hall
Public Talk: Sabine Jeck-Thole, Jürgen Kübler
Date: Monday, 26/Mar/2018
8:40am
-
10:00am
AD I: Adaptives Design I
Location: H20-5 Lecture Hall
Chair: Geraldine Rauch
Invited talk: Thomas Jaki
 

Master Protocols: Chances and challenges in drug development

Benjamin Hofner


Impact of biomarkers’ positivity prevalence on recruitment time and statistical properties in umbrella trials

Miriam Kesselmeier, André Scherag


Multi-arm multi-stage clinical trials: Design and some practical experiences

Thomas Jaki

SA I: Safety Assessments I
Location: H22-1 Lecture Hall
Chair: Anja Helena Loos
Invited talk: Conny Berlin
 

Invited Talk: Safety Assessments

Conny Berlin


On estimands and the analysis of adverse events at varying follow-up times in the benefit assessment of therapies: recommendations by the ATF/APF project group

Steffen Unkel, Marjan Amiri, Claudia Ose, Frank Langer, Guido Skipka, Norbert Benda, Carsten Schwenke, Dietrich Knoerzer, Tanja Proctor, Claudia Schmoor, Jan Beyersmann, Florian Voss, Kristina Unnebrink, Friedhelm Leverkus, Tim Friede


Quantitative assessment of adverse events in clinical trials – comparison of methods

Norbert Hollaender, Juan Gonzalez-Maffe

Ba I: Bayes-Statistik I
Location: H22-2 Lecture Hall
Chair: Reinhard Vonthein
Invited Talk: Joachim Gerß
 

A design-by-treatment interaction model for network meta-analysis and meta-regression with integrated nested Laplace approximations

Burak Kürsad Günhan, Tim Friede, Leonhard Held


A Bayes view on negative variance components

Gerhard Nehmiz


Planning a randomized controlled trial in pediatric oncology: A Bayes design with informative prior distribution can reduce the required sample size, yet providing type I error control

Joachim Gerß

ML I: Maschinelles Lernen und Big Data Analyse I
Location: H23-3 Lecture Hall
 

Incorporating interaction effects in trait prediction using MB-MDR

Damian Gola, Inke R. König


Sampling uncertainty versus method uncertainty: a general framework with applications to omics biomarker selection

Simon Klau, Marie-Laure Martin-Magniette, Anne-Laure Boulesteix


Priority-Lasso: a simple hierarchical approach to the prediction of clinical outcome using multi-omics data

Simon Klau, Vindi Jurinovic, Roman Hornung, Tobias Herold, Anne-Laure Boulesteix


Identification of typical patterns in the circadian activity rhythm of patients with mild cognitive impairments

Konrad Neumann

MM: Mathematische Modelle in der Medizin und Biologie
Location: H23-4 Lecture Hall
 

Mathematische Modellierung zur Schilddrüsenfunktion bei Morbus Basedow

Janina Haug, Eva Herrmann, Klaus Badenhoop, Diana Schork, Christoph Langenstein, Gesine Meyer


A multiple comparison procedure for overdispersed multinomial data

Charlotte Vogel, Frank Schaarschmidt, Ludwig A. Hothorn


Mathematical models for the prognosis and diagnosis of sepsis using a SIRS algorithm and ICU routine parameters

Ümniye Balaban, Verena Schneider-Lindner, Timo Sturm, Holger Lindner, Manfred Thiel, Christel Weiss


3D Spatially Resolved Models of the Hepatitis C Genome Replication Cycle

Markus M. Knodel, Arne Nägel, Sebastian Reiter, Alfio Grillo, Paul Targett-Adams, Eva Herrmann, Gabriel Wittum

.
Location: S22-1 Seminar Room
10:00am
-
10:30am
Kaffeepause
10:30am
-
12:00pm
Opening: Key Note Martin Schumacher
Location: H20-5 Lecture Hall
 

Dynamic prediction: A challenge for biostatisticians, but highly needed by patients, people and physicians

Martin Schumacher

12:00pm
-
1:00pm
Mittagspause
AG-Leiter Sitzung
Location: S20-6 Seminar Room
Time 12:05 - 12:50
1:00pm
-
2:20pm
.
Location: H20-5 Lecture Hall
SA II: Safety Assessments II
Location: H22-1 Lecture Hall
Chair: Conny Berlin
 

Multi-state Model for the Analysis of an Association between Safety and Efficacy Events

Juliane Manitz, Anja H. Loos, Arthur Allignol, Isabella Zwiener, Anja von Heydebreck


Adverse Event Discovery for Spontaneous Reporting Systems: A Systematic Comparison

Louis Dijkstra, Marco Garling, Ronja Foraita, Iris Pigeot


Comparing three modelling strategies to detect an non-constant hazard in signal detection of adverse drug reactions

Odile Sauzet, Victoria Cornelius

Ba II: Bayes-Statistik II
Location: H22-2 Lecture Hall
Chair: Gerhard Nehmiz
Invited talk: Christel Faes
 

Hierarchical Models for Count Data

Christel Faes


Bayesian Sample Size Calculation – a Critical Review of Expected Power and Probability of Success.

Kevin Kunzmann, Meinhard Kieser


Eine Meta-Analyse individueller, aggregierter und unvollständiger aggregierter Daten

Reinhard Vonthein, Alexander Jobs

ML II: Maschinelles Lernen und Big Data Analyse II
Location: H23-3 Lecture Hall
Invited talk: Elena Marchiori
 

Assessing false positive findings in a viral detection pipeline using high-throughput sequencing data

Jochen Kruppa, Klaus Jung


Recovery of IPD inferences from key IPD summaries only: Applications to research reproduction and synthesis

Federico Bonofiglio


Invited Talk: Machine Learning

Elena Marchiori

YSS: Young Statistician Session
Location: H23-4 Lecture Hall
 

Size Estimation for Pilot Animal Experiments by Using a Markov Chain Monte Carlo Approach

Andreas Allgöwer, Benjamin Mayer


An application of Bayesian logistic regression models with covariates for dose finding in cancer phase I trials

Moritz Pohl, Daniela Fischer, Jan Beyersmann, Kathrin Stucke-Straub


Evaluating long-term in uenza forecasts from spatio-temporal model components

Kelly Reeve, Leonhard Held


Application of weighted risk scores to estimate the relative contribution of pollution, life style and genetics to skin aging

Junior Awounvo, Tamara Schikowski, Jean Krutmann, Katja Ickstadt, Anke Hüls

MT I: Multiples Testen I
Location: S22-1 Seminar Room
Chair: Thorsten Dickhaus
 

Probability inequalities between one- and two-sided union-intersection tests

Helmut Finner


Evaluation of multiple prediction models

Max Westphal, Werner Brannath


Estimating the proportion of true null hypotheses under arbitrary dependency

Thorsten Dickhaus, André Neumann, Taras Bodnar

2:20pm
-
2:50pm
Kaffeepause
2:50pm
-
4:30pm
Nachwuchspreise
Location: H20-5 Lecture Hall
.
Location: H22-1 Lecture Hall
ÖFL I: Statistik in der Ökologie, Forst- und Landwirtschaft I
Location: H22-2 Lecture Hall
Chair: Hans-Peter Piepho
Session time 14:50 - 16:10

Invited talk: Emlyn Williams
 

Invited Talk: Statistics in Agriculture, Forestry and Ecology

Emlyn Williams


Optimal Designs for the Prediction of Individual Parameters in Multiple Group Models with Random Coefficients

Maryna Prus


Posterior Probabilities of Genome-Wide Associations in Backcross Families

Manuela Reichelt, Manfred Mayer, Friedrich Teuscher, Norbert Reinsch

BI I: Statistische Methoden in der Bioinformatik I
Location: H23-3 Lecture Hall
Session time 14:50 - 16:10
 

The right word in the right place: Optimizing codon usage for protein translation

Jan-Hendrik Trösemeier, Sophia Rudorf, Holger Loessner, Benjamin Hofner, Andreas Reuter, Thomas Schulenborg, Ina Koch, Isabelle Bekeredjian-Ding, Reinhard Lipowsky, Christel Kamp


Optimal Selection of Genetic Variants for Adjustment of Population Stratification in European Association Studies

Regina Brinster, Dominique Scherer, Justo Lorenzo Bermejo


Identication of SNP interactions associated with survival time using survivalFS

Tobias Tietz, Silvia Selinski, Klaus Golka, Jan Hengstler, Stephan Gripp, Katja Ickstadt, Ingo Ruczinski, Holger Schwender


Better regression models for the analysis of methylation data

Agnes Gambietz, Dominic Edelmann, Axel Benner

FT: Freie Themen
Location: H23-4 Lecture Hall
Session time 14:50-16:10
 

An Augmented Likelihood Ratio Index for Categorical Response Models

Ejike Richard Ugba, Jan Gertheiss


Guidance for the selection of variables and functional form for continuous variables – Why and for whom?

Willi Sauerbrei


Graphical principles for creating effective data visualizations

Mark Baillie, Julie Jones, Baldur Magnusson, Alison Margolskee, Marc Vandemeulebroecke


On the implications of influential points for the selection and reproducibility of MFP models

Yessica Fermin, Ewelina Kotwa, Patrick Royston, Willi Sauerbrei

MT II: Multiples Testen II
Location: S22-1 Seminar Room
Chair: Thorsten Dickhaus
Session time 14:50-16:10
 

The gatekeeping approach in the world of animal studies - benefits and limitations

Benjamin Mayer, Vicky Stahl, Martina Kron


Considerations on Model-Based approaches for Proof of Concept in Multi-Armed Studies

Tobias Mielke


Clinical trials with multiple objectives – optimal rejection regions based on Neyman-Pearson tests

Julia Maria Niewczas, Carl-Fredrik Burmann, Lisa Hampson, Martin Posch, Franz König

4:10pm
-
4:40pm
Pause
4:40pm
-
6:00pm
.
Location: H20-5 Lecture Hall
NP I: Nichtparametrische Methoden I
Location: H22-1 Lecture Hall
Chair: Arne Bathke
 

Resampling-Based Inference for Comparing the Reliability of Tests

Maria Umlauft, Ali Ünlü, Markus Pauly


Tree-Based Modelling of Varying Coefficient Terms

Moritz Berger, Gerhard Tutz, Matthias Schmid


Asymptotics of a non-Markov state transition probability estimator with applications to the expected length of stay

Dennis Dobler, Andrew C. Titman


Diskrete Mischverteilungsmodelle für nichtparametrische Überlebenszeitanalyse ohne Kovariate

Annegret Mucha, Peter Schlattmann

KS I: Klinische Studien I
Location: H22-2 Lecture Hall
 

Reflections on statistical methods used for comparison of quality attributes in drug development

Ina-Christine Rondak


An evaluation of statistical approaches for the comparative assessment of quality attributes in drug development

Florian Klinglmüller, Thomas 1 Lang


ERDO - Eine Anleitung zur Bestimmung der "best practice" Randomisierung für eine Klinische Studie

Nicole Heussen, Ralf-Dieter Hilgers


Carry-over effects in multi-arm cohort stepped wedge designs.

Ann Christina Foldenauer

BI II: Statistische Methoden in der Bioinformatik II
Location: H23-3 Lecture Hall
Invited Talk: Raivo Kolde
 

Plasmode data sets: a real-life data simulation with application on RIP-Seq experiments

Diana Tichy, Axel Benner


Demonstrating an association between a clinical covariate and multiple analytes, partly with detecting limits, in cross-sectional metabolomics data

Ludwig Hothorn, Paola Ferrario


Invited Talk: Statistical Bioinformatics

Raivo Kolde

Es I: Estimands and causal inference in randomized clinical trials
Location: H23-4 Lecture Hall
Chair: Ann-Kristin Leuchs
Invited talk: Ian White
 

Choosing estimands and estimating them in randomised controlled trials with treatment changes

Ian R White


Using principal stratification to address post-randomization events: A case study

Baldur Magnusson


Causal inference in randomized trials and observational epidemiology: what can each one teach the other?

Jack Bowden

ÖFL II: Statistik in der Ökologie, Forst- und Landwirtschaft II
Location: S22-1 Seminar Room
Chair: Hans-Peter Piepho
 

A combined physical-genetic map for dairy cattle

Alexander Hampel, Friedrich Teuscher, Dörte Wittenburg


Auswertungsstrategie und Ergebnisdarstellung eines Dauerversuches für zwei Auswertungszeiträume

Bärbel Kroschewski, Christel Richter


More on computer-generated augmented designs

Nha Vo-Thanh, Hans-Peter Piepho

7:00pm
-
8:30pm
Empfang im Römer
Date: Tuesday, 27/Mar/2018
8:40am
-
9:20am
.
Location: H20-5 Lecture Hall
.
Location: H22-1 Lecture Hall
Fortbildung/Workshop Arbeitsgruppe Biometrie in der Ethikkommission I
Location: H22-2 Lecture Hall
ML III: Maschinelles Lernen und Big Data Analyse III
Location: H23-3 Lecture Hall
 

Distributed multivariable modeling for signature development under data protection constraints

Daniela Zöller, Stefan Lenz, Harald Binder


Modeling of the immunome expression in lung cancer using deep learning - effect of regularization and independent training data

Moritz Hess, Stefan Lenz, Harald Binder

KS II: Klinische Studien II
Location: H23-4 Lecture Hall
 

Fallzahlplanung bei binären und normalverteilten Zielgrößen im unverbundenen Zweistichproben-Vergleich über Konfidenzintervalle unter Einführung eines nominellen Power-Parameters

Berit Geis, Sabrina Tulka, Frank Krummenauer


Querschnittsstudie zur Qualität berichteter Fallzahlplanungen in Publikationen von RCTs zur Versorgung von AMD-Patienten

Sabrina Tulka, Berit Geis, Frank Krummenauer

.
Location: S22-1 Seminar Room
9:20am
-
9:40am
Kurze Pause
9:40am
-
11:00am
.
Location: H20-5 Lecture Hall
MA I: Meta Analysis I
Location: H22-1 Lecture Hall
Chair: Guido Knapp
 

An empirical example of a network meta-analysis combining count and hazard ratio statistics

Svenja Seide, Katrin Jensen


Freeman-Tukey Double Arcsine Transformation in Meta-Analysis of Single Proportions

Guido Schwarzer, Gerta Rücker


Meta-analysis of transcriptome expression profiles after West-Nile-Fever-infections – benefits and limitations

Klaus Jung


A systematic survey shows that reporting and handling of missing outcome data in networks of interventions is poor

Loukia Spineli, Juan Jose Yepes-Nuñez, Holger Schünemann

Fortbildung/Workshop Arbeitsgruppe Biometrie in der Ethikkommission II
Location: H22-2 Lecture Hall
Di: Diagnosestudien
Location: H23-3 Lecture Hall
Chair: Annika Hoyer
Chair: Antonia Zapf
Invited talk: Patrick Bossuyt
 

Invited Talk: Diagnostic Trials

Patrick Bossuyt


Adaptive designs for diagnostic trials - in comparison to treatment studies

Antonia Zapf


A quasi-nonparametric model for the meta-analysis of full ROC curves

Annika Hoyer, Oliver Kuss

Su I: Überlebenszeitanalysen I
Location: H23-4 Lecture Hall
 

A weighted combined effect measure for the analysis of a composite time-to-first event endpoint

Ann-Kathrin Ozga, Geraldine Rauch


Analyzing the effect of critical drug discontinuation on adverse pregnancy outcomes

Tobias Bluhmki, Anne-Katrin Fietz, Tatjana Tissen-Diabaté, Regina Stegherr, Stephanie Padberg, Christof Schäfer, Jan Beyersmann, Reinhard Meister


Estimating cumulative incidence functions in situations with dependent left-truncation

Regina Stegherr, Jan Beyersmann, Christof Schäfer, Reinhard Meister, Arthur Allignol


Subdistribution Hazards Models for Competing Risks in Discrete Time

Matthias Schmid, Moritz Berger, Jan Beyersmann

KS III: Klinische Studien III
Location: S22-1 Seminar Room
 

Optimal designs for phase II/III drug development programs including rules for discounting of phase II results

Stella Preussler, Marietta Kirchner, Meinhard Kieser


Towards evidence-based biostatistics: lessons from clinical research on the role and design of studies comparing methods

Anne-Laure Boulesteix, Harald Binder, Rory Wilson, Michal Abrahamowicz, Willi Sauerbrei, Alexander Hapfelmeier


A Biomarker-Stratified Design with Therapeutic Recommendations for Each Subgroup

Darja Tutschkow, Nina Timmesfeld


A comparison of subgroup identification methods in clinical drug development

Cynthia Huber, Norbert Benda, Tim Friede

11:00am
-
11:30am
Kaffeepause
11:30am
-
12:50pm
.
Location: H20-5 Lecture Hall
MA II: Meta Analysis II
Location: H22-1 Lecture Hall
Chair: Christian Röver
Invited talk: Ian White
 

A comparison of arm-based and contrast-based approaches to network meta-analysis

Ian R White, Becky M Turner, Amalia Karahalios, Georgia Salanti


Likelihood-based random-effects meta-analysis of few studies: An empirical investigation and a simulation study

Svenja Seide, Christian Röver, Tim Friede


Evaluating the effects of complex interventions using meta-analytical models: a methodological review

Maria Petropoulou, Orestis Efthimiou, Georgia Salanti, Dimitris Mavridis

LD I: Lehre und Didaktik I
Location: H22-2 Lecture Hall
 

‘I am better than you’ – How social and environmental factors affect human learning processes

Christoph Borzikowsky


Bayes-Statistik in der Lehre für Anfänger und Anwender - sinnvoll, notwendig, möglich?

Hubert Merkel


Einsatz verschiedener interaktiver Lehrformate - Können Gummibärchen den Lernerfolg verbessern?

Manuel Feißt, Anja Sander, Kunzmann Kevin, Kieser Meinhard


A cooperative learning and flipped classroom approach for a seminar in statistics for medical students

Bernhard Haller, Alexander Hapfelmeier, Kurt Ulm

Ep I: Statistische Methoden in der Epidemiologie I
Location: H23-3 Lecture Hall
Chair: Irene Schmidtmann
Chair: Annika Hoyer
Invited talk: Ruth Keogh
 

Invited Talk: Statistical Methods in Epidemiology

Ruth Keogh


Adjusting for response misclassification in a study on age-related macular degeneration

Felix Günther, Caroline Brandl, Klaus Stark, Heid Iris, Küchenhoff Helmut


Bayes-Schätzer im Illness-Death Modell chronischer Erkrankungen: Relative Sterblichkeit bei Typ 2 Diabetes

Ralph Brinks, Thaddäus Tönnies, Annika Hoyer

Su II: Überlebenszeitanalysen II
Location: H23-4 Lecture Hall
Invited talk: Jon Michael Gran
 

Investigating Time-dependent Exposures Using Past Information In Non-standard Nested Case-Control Designs

Jan Feifel, Jan Beyersmann


A comparison of statistical methods for analysing recurrent exacerbations in COPD-trials under dependent treatment discontinuation

Gerrit Toenges, Florian Voss, Antje Jahn-Eimermacher


Invited Talk: Survival Analysis

Jon Michael Gran

RD: Rare Diseases
Location: S22-1 Seminar Room
Invited talk: Kit Roes
 

Invited Talk: Rare Diseases

Kit Roes


IDEAL - New developments on Design and Analysis of Small Population Group Trials

Ralf-Dieter Hilgers, Nicole Heussen


Randomized building blocks: A plea to provide best evidence in trials under sample size restrictions

Kristina Weber, Florian Lasch, Mwe Mwe Chao, Koch Armin

12:50pm
-
1:35pm
AG-Sitzungen
Mittagspause mit Poster Session
Location: Foyer Haus 23, 1. OG
1:35pm
-
2:20pm
PP: Poster Session Präsentationen
Location: Foyer Haus 23, 1. OG
 

50 Jahre Biometrie in Magdeburg

Friedrich-Wilhelm Röhl, Siegfried Kropf


Kosteneffektivität der DFG-Nachwuchsakademie „Klinische Studien“ – Investition des Förderers in Relation zur akademischen Verwertung durch die Teilnehmenden

Levka Dahmen, Frank Krummenauer


Einbindung von EbM-Elementen in das Seminar Q1/Biometrie: das Lehrprojekt „EbM-Corner“

Rainer Muche, Friederike Rohlmann, Marianne Meule, Benjamin Mayer


Multizentrischer Survey zur Vertrautheit klinisch tätiger Ärztinnen und Ärzte eines Universitätsklinikums mit gängigen Kenngrößen der Evidenz-basierten Medizin

Sünje-Theresa Ahrens, Sabrina Tulka, Frank Krummenauer


Graphical Principles Cheat Sheet

Mark Baillie, Alison Margolskee, Baldur Magnusson, Andrew Wright, Ruquan You, Ivan-Toma Vransesic, Marc Vandemeulebroecke


Testing treatment effects in nested subgroups with adjustment for baseline covariates: Testing procedure, sample size determination and blinded sample size reestimation

Roland Gerard Gera, Tim Friede


Evaluation verteidigter Dissertationsschriften zum „Dr. med. (dent.)“ bezüglich methodischer Qualitäts-Indikatoren in Anlehnung an das CONSORT-Statement zur transparenten Berichterstattung Klinischer Studien

Jana Hohage, Sabrina Tulka, Frank Krummenauer


A list of A-efficient treatment-control designs

Kazuhiro Ozawa, Shinji Kuriki


Establishing a database for the German Patient Blood Management Network to monitor its safety and effectiveness

Elke Schmitt, Kai Zacharowski, Christoph Füllenbach, Eva Herrmann, Patrick Meybohm


BMI trajectories during puberty among patients with type 1 diabetes - a longitudinal group-based modeling approach

Anke Schwandt, Julia Hermann, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Oliver Kuß, Joachim Rosenbauer, Reinhard Holl


Fast and reliable detection of antibiotic resistance by real-time analysis of bacterial growth

Matthias Borowski, Görlich Dennis, Idelevich Evgeny, Hoy Matthias, Becker Karsten


Identifying the transmission route of influenza A(H1N1) 2009 in Japan by epidemiological and non-epidemilogical data

Yusuke Asai, Hiroshi Nishiura


Modelling cost-effectiveness of genetic testing for autism

Wolfgang Rudolph-Rothfeld, Reinhard Vonthein


AccuFusion: A new statistical algorithm for detecting gene fusions in RNA-Seq data

Xiaoping Su, Gabriel Malouf


Identifying differential distributions for single-cell RNA sequencing data comprising biological replicates

Roman Schefzik


Splitting on categorical predictors in random forests

Marvin N. Wright


On the Finding of the Schuirmann Constant

Christian Palmes, Erich Bluhmki


P-value approximations for maximally selecteted chi square statistics

Björn-Hergen Laabs, Marvin N. Wright, Inke R. König


Pathway analysis with left-censored data

Pavel Tafo, Nina Timmesfeld


Methods for left-censored biomarker data: A simulation study in the two-sample case

Dominik Thiele, Inke R König


Gewichtete nichtparametrische Rangtests

Annette Lehn, Eva Herrmann


Simulation Study Comparing Different Propensity Score Methods

Dimitra Bon, Ümniye Balaban, Eva Herrmann


Comparison of propensity score methods in the analysis of rare events in pregnancy: challenges in treatment effect estimation

Tatjana Tissen-Diabaté, Anne-Katrin Fietz, Maria Hoeltzenbein, Stephanie Padberg, Reinhard Meister


Empirische Güteeigenschaften statistischer Verfahren zu Meta-Analysen diagnostischer Studien

Annika Strömer, Julia Rey, Eva Herrmann


A hierarchical Bayesian model for an in vitro-in vivo correlation (IVIVC)

Elvira M. Erhardt, Moreno Ursino, Tom Jacobs, Jeike Biewenga, Mauro Gasparini

2:20pm
-
4:00pm
NM: Netzwerk-Metaanalysen
Location: H20-5 Lecture Hall
Chair: Ulrike Krahn
Chair: Ralf Bender
Invited talk: David Phillippo
 

Population-adjusted treatment comparisons: Overview of approaches and recommendations from the NICE DSU

David Phillippo


Network meta-analysis of treatment combinations

Gerta Rücker, Guido Schwarzer


Estimating the variance for heterogeneity in arm-based network meta-analysis

Hans-Peter Piepho, Laurence Madden, James Roger, Roger Payne, Emlyn Williams


Identifying and assessing inferior treatments in network meta-analysis with control of the family-wise error rate

Jochem König

NP II: Nichtparametrische Methoden II
Location: H22-1 Lecture Hall
Chair: Markus Pauly
Invited talk: Jan de Neve
 

A Frequency-Domain Model Selection Criterion for Dynamic Factor Models

Natalia Sirotko-Sibirskaya


Nonparametric MANOVA in Mann-Whitney effects

Sarah Friedrich, Dennis Dobler, Markus Pauly


A Fast and Robust Way to Estimate Overlap of Niches, and Draw Inference

Arne Bathke, Judith Parkinson, Wolfgang Trutschnig


Invited Talk: Nonparametric Statistical Methods

Jan de Neve

LD II: Lehre und Didaktik II
Location: H22-2 Lecture Hall
 

Weiterbildung zum Medical Data Scientist – Konzept für ein Zertifikat an der Universität Heidelberg

Marietta Kirchner, Meinhard Kieser, Katharina Hees, Lorenz Uhlmann, Kevin Kunzmann


Lernzielkatalog Biometrie: Hintergrund, Vorarbeiten und weitere Planung

Jochen Kruppa, Geraldine Rauch


Wie kann man bei der biometrischen Betreuung an exakte Verfahren für das Arbeiten mit Kontingenztabellen heranführen?

Udo Rempe


p-Hacking and other common forms of statistical malpractice in medical research –ideas to effectively address them

Ulrike Grittner, Bob Siegerink, Jessica Lee Rohmann, Alice Schneider, Geraldine Rauch, Sophie Piper

Ep II: Statistische Methoden in der Epidemiologie II
Location: H23-3 Lecture Hall
Chair: Ralph Brinks
 

A plea for randomization: Lessons learned from a post-hoc analysis of the DIG trial

Lukas Malte Aguirre Dávila, Kristina Weber, Udo Bavendiek, Johann Bauersachs, Salim Yusuf, Armin Koch


Use of resampling methods to account for uncertainty arising from model selection

Jakob Schöpe, Abdelshafi Bekhit, Gudrun Wagenpfeil, Antonius Schneider, Stefan Wagenpfeil


Causal Reasoning for Censoring and Drop-Out

Vanessa Didelez


Chronic health conditions, educational support and school performance in the first school year: Investigating the role of educational support as a mediator variable in the ikidS study

Isabell Hoffmann, Jochem König, Michael Urschitz


Comparing apples and oranges? Should propensity scores be used for matching?

Ulrike Grittner, Jessica Lee Rohmann, Alice Schneider, Tobias Kurth, Konrad Neumann

Su III: Überlebenszeitanalysen III
Location: H23-4 Lecture Hall
 

A simulation study comparing confidence interval estimators for the changepoint of favourable treatment

Bernhard Haller, Alexander Hapfelmeier, Kurt Ulm


Intermediate endpoints for gating of early phase clinical trials with applications in cancer immunotherapy

Markus C Elze, Jiawen Zhu, David Dejardin, Xian He, Lijia Wang, Wei Zhang, Francesca Michielin, Ulrich Beyer, Daniel Sabanes Bove


Restricted Mean Survival Time and it's Alternatives Facing Non-Proportional Hazards

Andre König


A Proportional Risk Model for Survival Analysis in Randomized Controlled Trials

Oliver Kuß, Annika Hoyer


More efficient treatment effect estimation in pre-specified subgroups displayed in forest plots for time-to-event outcomes

Marcel Wolbers, Ke Li, Kaspar Rufibach

 
4:00pm
-
4:30pm
Kaffeepause
4:30pm
-
6:30pm
Mitgliederversammlung IBS-DR
Location: H20-5 Lecture Hall
7:30pm
-
10:00pm
Conference Dinner
Date: Wednesday, 28/Mar/2018
8:50am
-
10:10am
.
Location: H20-5 Lecture Hall
AD II: Adaptives Design II
Location: H22-1 Lecture Hall
Chair: Werner Brannath
 

Enhancing phase II trials by inclusion of matched control patients – the Matched-Threshold-Crossing (MTC) design

Johannes Krisam, Dorothea Weber, Richard F. Schlenk, Meinhard Kieser


Timing of the interim analysis in adaptive enrichment designs with sample size reassessment

Laura Benner, Meinhard Kieser


Sample size calculation for analysis of covariance models with multiple random covariates

Georg Zimmermann, Meinhard Kieser, Arne C. Bathke


Group sequential designs with robust semiparametric recurrent event models

Tobias Mütze, Ekkehard Glimm, Heinz Schmidli, Tim Friede

Schülerveranstaltung I
Location: H22-2 Lecture Hall
Es II: Estimands: Communicational challenges
Location: H23-3 Lecture Hall
Chair: Kaspar Rufibach
 

Estimands: from monologues to dialogues

Ina-Christine Rondak


The Estimands Concept - Experiences when Introducing the Concept in a Global Development Organization

Miriam Tamm, Christoph Gerlinger, Michael Kunz


Statistical and Operational Considerations in Longitudinal Studies Under the Estimand Framework

Lisa Squassante, Giuseppe Palermo, Kaspar Rufibach, Markus Abt

SP I: Statistics in Practice I
Location: H23-4 Lecture Hall
 

Education for Statistics in Practice: Dynamic prediction in survival analysis

Hein Putter

EB: Extrapolation, Bridging and Borrowing Information
Location: S22-1 Seminar Room
 

Incorportating historical data in two-armed clinical trials with binary outcome

Manuel Feißt, Kieser Meinhard


Appropriate statistical measures for decision making after exploratory cut-off selection

Heiko Götte, Marietta Kirchner, Meinhard Kieser


Robust extrapolation in random-effects meta-analysis

Christian Röver, Simon Wandel, Tim Friede


Statistical aspects of project attrition in early clinical development: challenges in translation of animal models to human disease

Stefan Klein, Ulbrich Hannes-Friedrich, Vradi Eleni, Vonk Richardus

10:10am
-
10:40am
Kaffeepause
10:40am
-
12:00pm
EL: Special Session Erich Lehmann
Location: H20-5 Lecture Hall
 

Leben und Werk Erich Lehmanns

Markus Neuhäuser, Ludwig Hothorn


Verliert Erich Lehmann's Hauptwerk durch das "ASA statement on p-values and statistical significance'' an Relevanz für die Biometrie?

Stefan Wellek


Control of the population-wise error rate in clinical trials with multiple populations

Werner Brannath, Charlie Hillner, Kornelius Rohmeyer


Hodges-Lehmann Schätzer

Edgar Brunner, Frank Konietschke

AD III: Adaptives Design III
Location: H22-1 Lecture Hall
Chair: Rene Schmidt
 

Adjusting Simon's two-stage design for heterogeneous populations using historical controls

Dominic Edelmann, Christina Habermehl, Richard Schlenk, Axel Benner


Konstruktion adaptiver Designs mittels stochastischer Integralprozesse für den Einstichproben-Log-Rank-Test

Robert Kwiecien, Rene Schmidt, Andreas Faldum


Optimized Rules and Performance Criteria for Adaptive Designs with Sample Size Recalculation

Geraldine Rauch, Kevin Kunzmann, Meinhard Kieser


BOP2: Bayesian Optimal Design for Phase II Clinical Trials with Simple and Complex Endpoints

Ying Yuan

Schülerveranstaltung II
Location: H22-2 Lecture Hall
Es III: Estimands: Applying the ICH E9 addendum
Location: H23-3 Lecture Hall
 

In Defence of the Hypothetical; Real Clinical Relevance, Real Importance

James Charles Bell, Frank Fleischer


The Estimand Framework Applied to Time-to-event Endpoints

Kaspar Rufibach


The concept of Estimands in the day to day practice of safety analyses: Both a blessing and a curse?

Armin Schüler, Anja Loos

SP II: Statistics in Practice II
Location: H23-4 Lecture Hall
HT: Health Technology Assessment
Location: S22-1 Seminar Room
Chair: Ralf Bender
 

Evidence synthesis for two populations: incorporating baseline comparisons in the research strategy

Florian Lasch, Kristina Weber, Armin Koch


Statistische Methoden zur Übertragbarkeit von Ergebnissen von Studienpopulationen auf Teilpopulationen

Lars Beckmann, Ulrich Grouven, Meinhard Kieser, Wiebke Sieben, Guido Skipka, Ralf Bender


Indirekte Vergleiche in der frühen Nutzenbewertung: Akzeptanz und Ablehnungsgründe in den Jahren 2011 bis 2016

Mandy Kromp, Corinna Kiefer, Sibylle Sturtz, Ralf Bender

12:00pm
-
12:30pm
Pause
12:30pm
-
2:00pm
Closing: Hauptvortrag Martin Posch
Location: H20-5 Lecture Hall
 

Multiplicity, Interim Analyses and Adaptations: Blurring the boundaries between confirmation and exploration?

Martin Posch


 
Contact and Legal Notice · Contact Address:
Conference: 64. Biometrisches Kolloquium 2018
Conference Software - ConfTool Pro 2.6.114
© 2001 - 2018 by H. Weinreich, Hamburg, Germany