Biomarkers of age-related diseases: studying Alzheimer’s Disease through an integrative serum metabolomic and lipoproteomic NMR-based approach

Alessia Vignoli¹, Giovanni Bellomo², Federico Paolini Paoletti³, Claudio Luchinat⁴, Lucilla Parnetti³, Leonardo Tenori¹

1: University of Florence, Italy; 2: Link Campus University, Italy; 3: University of Perugia, Italy; 4: Giotto Biotech, S.R.L., Italy

Differential Responses of Human Astrocytes to Amyloid β1-42 Treatment: a comparative study between astrocytes from healthy individuals and Alzheimer's patients

Sara Ristori, Elisa Bientinesi, Gianmarco Bertoni, Alessandra Bigi, Daniela Monti

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy

Gemcitabine-Induced Astrocyte Senescence: Different Responses in Alzheimer’s Disease vs. Healthy Cells

Gianmarco Bertoni, Sara Ristori, Elisa Bientinesi, Daniela Monti

University of Florence, Italy

The blood molecular signature of progressive carotid stenosis: the ongoing validation phase.

Chiara Bontempo¹, Lucio Publio Gallo¹, Marco Mattiacci², Enrico Giampieri¹, Sabrina Valente^1,2, Annalisa Astolfi^1,2, Gaetano La Manna^1,4, Gianandrea Pasquinelli^1,3, Mauro Gargiulo^1,5, Miriam Capri¹

1: DIMEC- Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum-Università di Bologna, Italy; 2: IRCCS-AOU, Bologna, Italy; 3: Pathology Unit, IRCCS-AOU, Bologna, Italy; 4: Nephrology, Dialysis and Renal Transplant Unit, IRCCS-AOU, Bologna, Italy; 5: Vascular Surgery Unit, IRCCS-AOU Bologna, Italy

The potential of a telomere-targeted therapy on lifespan and healthspan of geriatric mice

Maria Elisa Giuliani¹, Giorgia Bigossi¹, Giovanni Lai¹, Serena Marcozzi¹, Fiorenza Orlando¹, Beatrice Bartozzi¹, Andrea Piccinini¹, Davide Perini¹, Sunday Segun Alimi¹, Alessia Oppezzo², Francesca Rossiello², Sara Sepe², Fabrizio d'Adda di Fagagna^2,3, Marco Malavolta^1,4

1: Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, IRCCS INRCA, 60121 Ancona, Italy; 2: IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy; 3: Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, Italy; 4: Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Via Tronto 10/a, 60020 Ancona, Italy

Where would you rather live? Blue and Green Zones of Longevity in Italy

Elisabetta Barbi, Giacomo Lanfiuti Baldi

Sapienza University of Rome, Italy

The role of Aging and Cognitive Reserve in Motor Imagery Ability: Behavioral Insights into Strategy Use

Bianca Monachesi¹, Stefania Lucia¹, Elisabetta Pisanu¹, Silvia Fornaro¹, Raffaella I. Rumiati^1,2

1: SISSA, Italy; 2: University of Tor Vergata, Italy

Evaluating frailty among older adults using a principal components-based indicator

Pietro Belloni

University of Padova, Italy

Change and Resistance in Digital Self-Care: Motivational Processes in Older Adults with Chronic Conditions

Daniela Lemmo¹, Fabrizio Mezza¹, Alessandra Cuomo², Antonio Bianco³, Antonella Di Donato², Vincenzo De Luca³, Maddalena Illario³, Guido Iaccarino², Maria Francesca Freda¹

1: Department of Humanities, University of Naples Federico II, Naples, Italy; 2: Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; 3: Department of Public Health, University of Naples Federico II, Naples, Italy

Administrative data for reproducible frailty assessment

Maurizio Nicolaio, Margherita Silan, Giovanna Boccuzzo

University of Padova, Italy

"Unveiling the Hidden Burden of Frailty in Burning Mouth Syndrome: A Multidimensional Case-Control Study on Physical, Cognitive, and Psychosocial Decline"

Daniela Adamo¹, Federica Canfora², Cristina D'Antonio³, Vincenzo De Luca², Jacopo Meglio², Gennaro Musella⁴, Giulia Ottaviani⁵, Maddalena Illario²

1: Link Campus University, Federico II University of Naples, Italy; 2: Federico II University of Naples, Italy; 3: Magna Grecia, Catanzaro, Italy; 4: University of Foggia; Italy; 5: University of Trieste, Italy

The impact of attentional mechanisms on reading ability in healthy aging

Sara Pegoraro^1,2,3, Simone Galati¹, Alessio Facchin⁴, Camilla Frontoni¹, Elena Rolandi⁵, Emanuela Bricolo¹, Lisa Saskia Arduino⁶, Roberta Daini^1,2,7

1: University of Milano-Bicocca, Italy; 2: Milan Centre for Neuroscience (NeuroMI), Milano, Italy; 3: Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden; 4: Research Center in Neuroscience, Magna Graecia University, Catanzaro Italy; 5: Golgi Cenci Foundation, Abbiategrasso (Milan), Italy; 6: Department of Human Sciences - LUMSA University, Rome, Italy; 7: IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy

Migrants and Ageing in Italy: A Multifarious Phenomenon

Daniela Carrillo, Patrizia Farina

university of Milan Bicocca, Italy

Enhancing health literacy to support family dementia caregivers: a community-based group intervention in primary care

Claudia Biagi¹, Chiara Milani¹, Claudia Rosi¹, Rachele Mei¹, Riccardo Barucci², Enrico Benvenuti², Giulia Naldini³, Lorenzo Baggiani³, Chiara Lorini¹, Guglielmo Bonaccorsi¹

1: Department of Health Sciences, University of Florence, Italy; 2: Geriatric Unit, Azienda USL Toscana Centro, Italy; 3: Department of Community Healthcare Network, Azienda USL Toscana Centro, Italy

Assisting Dementia caregivers through AI-CARE: a study protocol for usability

Danilo Atripaldi^1,2, Fabio Matascioli¹, Ludovico Piccolo¹, Nadia Conte¹, Agostino Borroso¹, Ilaria Chirico³, Riccardo Pronzato⁴, Sara Trolese³, Rabih Chattat³

1: TAMLab - Social Enterprise, Naples, Italy; 2: Department of Advanced Medical and Surgical Studies, University of Campania “Luigi Vanvitelli”, Naples, Italy; 3: Department of Psychology, University of Bologna, Italy; 4: Department of Sociology and Business Law, University of Bologna, Italy

The co-design and development of an e-learning platform for informal, formal and migrant caregivers of people with dementia: the AGE-IT project

Rabih Chattat¹, Sara Trolese¹, Sara Santini², Georgia Casanova², Serena Cancellieri², Antonella Golino³, Daniela Grignoli³, Veronica Moretti¹, Riccardo Pronzato¹, Ilaria Chirico¹

1: University of Bologna, Italy; 2: IRCCS INRCA National Institute of Health and Science on Ageing, Centre for Socio-Economic Research on Aging, Ancona, Italy; 3: University of Molise, Campobasso, Italy

Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tumour effect on osteosarcoma cells

Elisa Bientinesi, Sara Ristori, Gianmarco Bertoni, Matteo Lulli, Daniela Monti

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy

Exploring the Synergistic Effect of a Senolytic Compound and a Probiotic on Healthspan and Lifespan in Aged Mice

Serena Marcozzi¹, Giorgia Bigossi¹, Maria Elisa Giuliani¹, Giovanni Lai¹, Marco Malavolta^1,2

1: IRCCS INRCA, Ancona, Italy; 2: Università Politecnica Delle Marche, Ancona, Italy.

Carnitine network and SASP: role of membrane transporters from SLC family

Mariafrancesca Scalise¹, Francesca Barone¹, Lara Console¹, Michele Galluccio¹, Annamaria Tonazzi², Nicola Giangregorio², Lorena Pochini^1,2, Cesare Indiveri^1,2

1: University of Calabria, Italy; 2: IBIOM-CNR, Bari Italy

A20 and TNIP3 attenuate NF-κB – mediated paracrine responses to hypoxia/hyperglycemia-induced endothelial senescence

Lara Russo, Serena Babboni, Serena Del Turco, Giuseppina Basta

Consiglio nazionale delle ricerche- Istituto di Fisiologia Clinica, Italy

Role of the TGN transport machinery in the regulation of SASP-components transport and secretion.

Rosaria Di Martino, Daniela Corda, Alberto Luini

Istituto degli Endotipi in Oncologia, Metabolismo ed Immunologia, Consiglio Nazionale delle Ricerche, Italy

Effects of Chemotherapy-Induced Golgi Alterations and Exploiting Senescence for Cancer Therapy

Fabiola Mascanzoni, Inmaculada Ayala, Daniela Spano, Roberta Iannitti, Antonino Colanzi

CNR, IEOMI Italy

A cytokine-based inflammaging score improves frailty-based prediction of long-term mortality in older adults.

Matilde Sbriscia¹, Sonia Fantone¹, Mirko Di Rosa², Francesca Marchegiani³, Rina Recchioni³, Giulia Matacchione³, Chiara Giordani³, Francesco Piacenza¹, Roberta Giacconi¹, Davide Gentilini^4,5, Luciano Calzari⁴, Carlo Forunato¹, Gretta Veronica Badillo Pazmay¹, Monia Cecati¹, Sara Caccese⁶, Emanuele Francini³, Rosanna Maniscalco¹, Maurizio Cardelli¹, Elena Tortato⁷, Federica Lenci⁸, Yuri Rosati⁹, Maurizio Burattini¹⁰, Roberto Antonicelli¹¹, Andrea Corsonello^12,13, Luca Soraci¹², Leonardo Biscetti¹⁴, Massimiliano Fedecostante¹⁵, Riccardo Sarzani^16,17, Marco Malavolta^1,16, Tiziana Casoli¹⁸, Maria Conte¹⁹, Antonio Domenico Procopio^3,16, Fabrizia Lattanzio⁶, Anna Rita Bonfigli⁶, Antonio Cherubini^15,16, Claudio Franceschi²⁰, Jacopo Sabbatinelli^3,16, Fabiola Olivieri^1,16

1: Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, IRCCS INRCA, Ancona, Italy; 2: Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, IRCCS INRCA, Ancona, Italy; 3: Clinic of Laboratory and Precision Medicine, IRCCS INRCA, Ancona, Italy; 4: Bioinformatics and Statistical Genomics Unit, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Italy; 5: Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; 6: Scientific Direction, IRCCS INRCA, Ancona, Italy; 7: Diabetology Unit, IRCCS INRCA, Ancona, Italy; 8: Unit of Nephrology and Dialysis, IRCCS INRCA, Ancona, Italy; 9: Respiratory Medicine, IRCCS INRCA, Osimo, Italy; 10: Internal Medicine, IRCCS INRCA, Osimo, Italy; 11: Cardiology Unit, IRCCS INRCA, Ancona, Italy; 12: Unit of Geriatric Medicine, IRCCS INRCA, Cosenza, Italy; 13: Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy; 14: Neurology Unit, IRCCS INRCA, Ancona, Italy; 15: Geriatria, Accettazione Geriatrica e Centro di ricerca per l'invecchiamento, IRCCS INRCA, Ancona, Italy; 16: Department of Clinical and Molecular Sciences (DISCLIMO), Università Politecnica delle Marche, Ancona, Italy; 17: Internal Medicine and Geriatrics, 'Hypertension Excellence Centre' of the European Society of Hypertension, Società Italiana per lo Studio dell'Aterosclerosi (SISA) LIPIGEN Centre, IRCCS INRCA, Ancona, Italy; 18: Center for Neurobiology of Aging, IRCCS INRCA, Ancona, Italy; 19: Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy; 20: Institute of Biogerontology, Lobachevsky State University, Nizhny Novgorod, Russia

Stable non-cohabiting relationships (Living Apart Together) and male sexual health: results from the EMAS population

Clotilde Sparano¹, Giammarco Alderotti², Giovanni Corona³, Giulia Rastrelli⁴, Linda Vignozzi⁴, Daniele Vignoli², Mario Maggi¹, EMAS group⁵

1: SODc Endocrinologia, Dipartimento di Scienze Biomediche, Sperimentali e Cliniche “Mario Serio”, Università degli Studi di Firenze, Firenze, Italia; 2: Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy; 3: Endocrinology Unit, Azienda USL Bologna, Bologna, Italy; 4: Andrology, Women’s Endocrinology and Gender Incongruence Unit, "Mario Serio", Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; 5: EMAS group

Fertility intentions of migrants in Italy: searching for sources of variation between men and women and across origins

THAIS GARCIA PEREIRO¹, GIUSEPPE GABRIELLI², ANNA PATERNO¹, SALVATORE STROZZA²

1: Università degli Studi di Bari Aldo Moro; 2: Università degli Studi di Napoli Federico II

The Impact of Spousal Loss on Life Satisfaction: Evidence from SHARE.

Lucia Zanotto, Chiara Ludovica Comolli, Roberto Impicciatore

University of Bologna, Italy

Re-partnering in mid- and later life in Italy

Revathi Palat Rao¹, Elena Pirani²

1: University of Florence, Italy, Italy; 2: University of Florence, Italy, Italy

Health and Union Dissolution After Midlife: A Dyadic Approach

Giammarco Alderotti, Daniele Vignoli, Carlos Gil

University of Florence, Italy

Pronatalist vs. Structural Approaches to Addressing Low Fertility: Lessons from the Italian Case

Raffaele Guetto, Daniele Vignoli

University of Florence, Italy

The Contribution of Medically Assisted Reproduction to Fertility in Italy

Alessandra Burgio¹, Cinzia Castagnaro¹, Gustavo De Santis², Daniele Vignoli², Agnese Vitali³

1: Istat, Italy; 2: University of Florence, Italy; 3: University of Trento, Italy

Women reproductive health in ageing society and private pubblic intervention

Sara Landini, Simona Viciani, Giulia Biagioni, Emilia Giusti

Unifi, Italy

The Cost of Loss: Unequal Bereavement effects in Later Life

Chiara Ludovica Comolli¹, Diego Pieroni², Valentina Ricci²

1: Università di Bologna, Italy; 2: INPS

New insights into fertility intentions and realizations through a longitudinal register of individuals in Italy

Cinzia Castagnaro¹, Eleonora Meli¹, Daniele Vignoli², Letizia Mencarini³

1: Istat, Italy; 2: University of Florence; 3: Bocconi University

Work-family trajectories and health: the role of partners’ crossover effects

Davide Gritti, Raffaele Grotti, Stefani Scherer

Trento University, Italy

Income and Fertility in Couples: New Evidence from Longitudinal Tax Data in Tuscany

Carlos J. Gil-Hernández¹, Daniele Vignoli¹, Raffaele Guetto¹, Marialuisa Maitino², Letizia Ravagli²

1: University of Florence, Department of Statistics, Computer Science, Applications, Italy; 2: Istituto Regionale per la Programmazione Economica della Toscana (IRPET), Italy

Modern Family: Transition to Single Parenthood and the Consequences for Well-Being

Andrea Ballerini, Raffaele Guetto

University of Florence, Italy

Attitudes towards ART: a vignette study

Daniele Vignoli¹, Valentina Tocchioni², Marco Cozzani³, Ester Lazzari⁴

1: Università degli Studi di Firenze, Italy; 2: Università degli Studi di Firenze, Italy; 3: Università degli Studi di Firenze, Italy; 4: Vienna Institute of Demography

Understanding Implementation of the Family and Community Nurse Role in Northern Italy: A Case Study

Erika Bassi^1,2, Erica Busca¹, Alberto Dal Molin^1,2

1: University of Piemonte Orientale, Italy; 2: Maggiore della Carità University Hospital, Italy

Explaining differential alignment in rural ageing: being on the track or sliding back?

FRANCESCA DONATI¹, TIZIANA NAZIO^1,2

1: Università del Piemonte Orientale, Italy; 2: Università di Torino

AGEITALY- A MULTI-PURPOSE STUDY ON ACTIONS, STRATEGIES AND POLICIES PROMOTING ACTIVE AND HEALTHY AGEING IN ALL ITALIAN POLICIES

Guido Giarelli, Marilin Mantineo, Olena Ignatenko, Nikolai Pagano, Ludovica Rossotti

UNIVERSITA' MAGNA GRAECIA, Italy

Active ageing policies in Italy: recent developments and future prospects

Davide Lucantoni, Andrea Principi

National Institute of Health and Science on Ageing (IRCCS-INRCA), Italy

Transitions in older age under the lens of active ageing: a scoping review

Marco Socci¹, Davide Lucantoni¹, Maria Vittoria Bufali², Andrea Principi¹

1: IRCCS INRCA - National Institute of Health and Science on Ageing, Ancona, Italy; 2: Bocconi University, Milan, Italy

Social participation and active ageing policies: from macro-context to individual responsibilities

CARMINE CLEMENTE

Università di Bari - Dipartimento FOR.PSI.COM., Italy

Designing for ageing well: development of design guidelines of gerontechnology to promote healthy and active ageing

Mattia Pistolesi, Iris Ayame Brunella Verzì, Francesca Tosi

University of Florence, Italy

Effects of pet ownership on physical performance in older outpatients: preliminary data from a pilot study

Greta Ceccarelli, Fiorella Aversano, Gilda Zondini, Ilaria Ambrosino, Ilenia Barbieri, Olimpia Martini, Arianna Tariello, Ludovica Ceolin, Giulia Spanalatte, Thierry Wenger, Giulia Rivasi, Enrico Mossello, Andrea Ungar

University of Florence and Division of Geriatric and high-intensity Care Medicine and Geriatric Cardiology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Care Work for Vulnerable Elderly People in a Comparative Perspective: The Role of the Family Caregiver in Italy, France, and Spain

Francesca Rotolo, Claudia Irti

Ca' Foscari University of Venice, Italy

Reproducing the future: a realistic necessity for an ageing society

Carlo Burelli

Università del Piemonte Orientale, Italy

Age and Gender Preferences in Job Opportunities: a Survey in Italian SMEs

Francesco Maura, Paola Profeta, Olivia Masi

Università Bocconi, Italy

Economic crisis and the wellbeing of the elderly in Italy: the long-term impact of the Great Recession

Loris Vergolini^1,2, Paolo Pasetti¹, Eleonora Vlach³

1: University of Bologna, Italy; 2: FBK-IRVAPP, Italy; 3: Goethe-Universität, Germany

Retirement migration, citizenship, and regulatory inconsistency: the Italian case between agency mobile and institutional constraints

Marco Alberio, Olivia Pini, Alice Lomonaco

University of Bologna

General Practitioners and Avoidable Hospitalizations in Italy's Aging Population.

Simone Ghislandi, Giulia Tarantino, Aleksandra Torbica, Irene Torrini

Bocconi University, Italy